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• W3215086295 endingPage "12531" @default.
• W3215086295 startingPage "12531" @default.
• W3215086295 abstract "Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic drugs with sleep-modifying side effects. Epilepsy patients with poor sleep quality have intensified seizure frequency and disease progression compared to their well-rested counterparts. A better understanding of the complex relationship between sleep and epilepsy is needed, since approximately 20% of seizures and more than 90% of sudden unexpected deaths in epilepsy occur during sleep. Emerging studies suggest that neuroinflammation, (e.g., the CNS immune response characterized by the change in expression of inflammatory mediators and glial activation) may be a potential link between sleep deprivation and seizures. Here, we review the mechanisms by which sleep deprivation induces neuroinflammation and propose that neuroinflammation synergizes with seizure activity to worsen neurodegeneration in the epileptic brain. Additionally, we highlight the relevance of sleep interventions, often overlooked by physicians, to manage seizures, prevent epilepsy-related mortality, and improve quality of life." @default.
• W3215086295 created "2021-12-06" @default.
• W3215086295 creator A5007481850 @default.
• W3215086295 creator A5015507358 @default.
• W3215086295 creator A5018370239 @default.
• W3215086295 creator A5030750209 @default.
• W3215086295 date "2021-11-20" @default.
• W3215086295 modified "2023-09-26" @default.
• W3215086295 title "Sleep Disruption Worsens Seizures: Neuroinflammation as a Potential Mechanistic Link" @default.
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