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• W3215118372 abstract "The step of identifying target molecules and elucidating the mode of action of bioactive compounds is a major bottleneck for drug discovery from phenotypic screening. Genetic screening for genes that affect drug sensitivity or phenotypes of mammalian cultured cells is a powerful tool to obtain clues to their modes of action. Chemical genomic screening systems for comprehensively identifying such genes or genetic pathways have been established using shRNA libraries for RNA interference-mediated mRNA knockdown or sgRNA libraries for CRISPR/Cas9-mediated gene knockout. The combination of chemical genomic screening in mammalian cells with other approaches such as biochemical searches for target molecules, phenotypic profiling, and yeast genetics provides a systematic way to elucidate the mode of action by converging various pieces of information regarding target molecules, target pathways, and synthetic lethal pathways." @default.
• W3215118372 created "2021-12-06" @default.
• W3215118372 creator A5040761742 @default.
• W3215118372 creator A5041480913 @default.
• W3215118372 date "2021-12-07" @default.
• W3215118372 modified "2023-10-16" @default.
• W3215118372 title "Mammalian Chemical Genomics towards Identifying Targets and Elucidating Modes‐of‐Action of Bioactive Compounds" @default.
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