Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215134919> ?p ?o ?g. }
- W3215134919 endingPage "104459" @default.
- W3215134919 startingPage "104459" @default.
- W3215134919 abstract "Invasive candidiasis is a healthcare-associated fungal infection with a high mortality rate. Neutrophils, the first line of defense during fungal infections, express the immunoregulatory Candida albicans receptors CEACAM1, CEACAM3, and CEACAM6. We analyzed the effects of specific antibodies on C. albicans-induced neutrophil responses. CEACAM6 ligation by 1H7-4B and to some extent CEACAM1 ligation by B3-17, but not CEACAM3 ligation by 308/3-3, resulted in the immediate release of stored CXCL8 and altered transcriptional responses of the C. albicans-stimulated neutrophils. Integrated network analyses and dynamic simulations of signaling cascades predicted alterations in apoptosis and cytokine secretion. We verified that CEACAM6 ligation enhanced Candida-induced neutrophil apoptosis and increased long-term IL-1β/IL-6 release in responses to C. albicans. CEACAM3 ligation, but not CEACAM1 ligation, increased the long-term release of pro-inflammatory IL-1β/IL-6. Taken together, we demonstrated for the first time that ligation of CEACAM receptors differentially affects the regulation of C. albicans-induced immune functions in human neutrophils." @default.
- W3215134919 created "2021-12-06" @default.
- W3215134919 creator A5001359351 @default.
- W3215134919 creator A5009297306 @default.
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- W3215134919 creator A5047698122 @default.
- W3215134919 creator A5050586206 @default.
- W3215134919 creator A5061881249 @default.
- W3215134919 creator A5068432868 @default.
- W3215134919 creator A5070610653 @default.
- W3215134919 creator A5071403660 @default.
- W3215134919 creator A5086002454 @default.
- W3215134919 creator A5086202312 @default.
- W3215134919 date "2022-01-01" @default.
- W3215134919 modified "2023-10-15" @default.
- W3215134919 title "Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially enhance the cytokine release of human neutrophils in responses to Candida albicans" @default.
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