Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215147198> ?p ?o ?g. }
- W3215147198 abstract "Given combined efforts of neuroscience and immunology, increasing evidence has revealed the critical roles of the immune system in regulating homeostasis and disorders of the central nervous system (CNS). Microglia have long been considered as the only immune cell type in parenchyma, while at the interface between CNS and the peripheral (meninges, choroid plexus, and perivascular space), embryonically originated border-associated macrophages (BAMs) and multiple surveilling leukocytes capable of migrating into and out of the brain have been identified to function in the healthy brain. Hypoxia-induced neuroinflammation is the key pathological procedure that can be detected in healthy people at high altitude or in various neurodegenerative diseases, during which a very thin line between a beneficial response of the peripheral immune system in maintaining brain homeostasis and a pathological role in exacerbating neuroinflammation has been revealed. Here, we are going to focus on the role of the peripheral immune system and its crosstalk with CNS in the healthy brain and especially in hypobaric or ischemic hypoxia-associated neuroinflammation." @default.
- W3215147198 created "2021-12-06" @default.
- W3215147198 creator A5007367310 @default.
- W3215147198 creator A5038796794 @default.
- W3215147198 date "2021-11-22" @default.
- W3215147198 modified "2023-10-13" @default.
- W3215147198 title "Multiple Roles of Peripheral Immune System in Modulating Ischemia/Hypoxia-Induced Neuroinflammation" @default.
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