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• W3215204927 abstract "The use of polymeric blends is a potential strategy to obtain novel nanotechnological formulations aiming at drug delivery systems. Saquinavir, an antiretroviral drug, was chosen as a model drug for the development of new stable liquid formulations with unpleasant taste masking properties. Three formulations containing different polymeric ratios (1:3, 1:1 and 3:1) were prepared and properly characterized by particle size distribution, zeta potential, pH, drug content and encapsulation efficiency measurements. The stability was verified by monitoring the zeta potential, particle size distribution, polydispersity index and drug content by 90 days. The light backscattering analysis was used to early identify possible phenomena of instability in the formulations. The in vitro drug release and saquinavir cytotoxicity were evaluated. The in vitro and in vivo taste masking properties were studied using an electronic tongue and a human sensory panel. All formulations presented nanometric sizes around 200 nm and encapsulation efficiency above 99%. The parameters evaluated for stability remained constant throughout 90 days. The in vitro tests showed a controlled drug release and absence of toxic effects on human T lymphocytes. The electronic tongue experiment showed taste differences for all formulations in comparison to drug solutions, with a more pronounced difference for the formulation with higher polycaprolactone content (3:1). This formulation was chosen for in vivo sensory panel evaluation which results corroborated the electronic tongue experiments. In conclusion, the polymer blend nanoformulation developed herein showed the promising application to incorporate drugs aiming at pharmaceutical taste-masking properties." @default.
• W3215204927 created "2021-12-06" @default.
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• W3215204927 date "2021-11-25" @default.
• W3215204927 modified "2023-10-18" @default.
• W3215204927 title "Polycaprolactone And Polycaprolactone Triol Blends To Obtain A Stable Liquid Nanotechnological Formulation: Synthesis, Characterization And In Vitro - In Vivo Taste Masking Evaluation" @default.
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• W3215204927 doi "https://doi.org/10.1080/03639045.2021.2010743" @default.
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• W3215204927 hasPublicationYear "2021" @default.
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