FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215258178> ?p ?o ?g. }

• W3215258178 abstract "Abstract Background Bladder cancer (BC) is one of the most common malignancies and has a relatively poor outcome worldwide. In this study, we attempted to construct a novel metabolism-related gene (MRG) signature for predicting the survival probability of BC patients. Methods First, differentially expressed MRGs between BC and normal samples were identified and used to construct a protein-protein interaction (PPI) network and perform mutation analysis. Next, univariate Cox regression analysis was utilized to select prognostic genes, and multivariate Cox regression analysis was applied to establish an MRG signature for predicting the survival probability of BC patients. Moreover, Kaplan-Meier (KM) survival analysis and receiver operating characteristic (ROC) analysis were performed to evaluate the predictive capability of the MRG signature. Finally, a nomogram based on the MRG signature was established to better predict the survival of BC. Results In the present study, 27 differentially expressed MRGs were identified, most of which presented mutations in BC patients, and LRP1 showed the highest mutation rate. Next, an MRG signature, including MAOB, FASN and LRP1, was established by using univariate and multivariate Cox regression analysis. Furthermore, survival analysis indicated that BC patients in the high-risk group had a dramatically lower survival probability than those in the low-risk group. Finally, Cox regression analysis showed that the risk score was an independent prognostic factor, and a nomogram integrating age, pathological tumor stage and risk score was established and presented good predictive ability. Conclusion We successfully constructed a novel MRG signature to predict the prognosis of BC patients, which might contribute to the clinical treatment of BC." @default.
• W3215258178 created "2021-12-06" @default.
• W3215258178 creator A5001129223 @default.
• W3215258178 creator A5006100271 @default.
• W3215258178 creator A5033131479 @default.
• W3215258178 creator A5037967253 @default.
• W3215258178 creator A5043069455 @default.
• W3215258178 creator A5078845886 @default.
• W3215258178 date "2021-11-24" @default.
• W3215258178 modified "2023-10-17" @default.
• W3215258178 title "Identification of a novel metabolism-related gene signature associated with the survival of bladder cancer" @default.
• W3215258178 cites W1971324216 @default.
• W3215258178 cites W1974277970 @default.
• W3215258178 cites W1996566824 @default.
• W3215258178 cites W2018561776 @default.
• W3215258178 cites W2035618305 @default.
• W3215258178 cites W2042354162 @default.
• W3215258178 cites W2050345155 @default.
• W3215258178 cites W2073277346 @default.
• W3215258178 cites W2075467661 @default.
• W3215258178 cites W2076494035 @default.
• W3215258178 cites W2086905232 @default.
• W3215258178 cites W2090846942 @default.
• W3215258178 cites W2091415498 @default.
• W3215258178 cites W2091853487 @default.
• W3215258178 cites W2101562875 @default.
• W3215258178 cites W2109242212 @default.
• W3215258178 cites W2117692326 @default.
• W3215258178 cites W2119000874 @default.
• W3215258178 cites W2125163561 @default.
• W3215258178 cites W2134730347 @default.
• W3215258178 cites W2143975632 @default.
• W3215258178 cites W2152455106 @default.
• W3215258178 cites W2155268547 @default.
• W3215258178 cites W2157244703 @default.
• W3215258178 cites W2159675211 @default.
• W3215258178 cites W2179438025 @default.
• W3215258178 cites W2208313734 @default.
• W3215258178 cites W2286754604 @default.
• W3215258178 cites W2414481435 @default.
• W3215258178 cites W2473162054 @default.
• W3215258178 cites W2551560376 @default.
• W3215258178 cites W2559804019 @default.
• W3215258178 cites W2588916311 @default.
• W3215258178 cites W2599135270 @default.
• W3215258178 cites W2605970468 @default.
• W3215258178 cites W2609464379 @default.
• W3215258178 cites W2744255196 @default.
• W3215258178 cites W2767633430 @default.
• W3215258178 cites W2790952843 @default.
• W3215258178 cites W2883576942 @default.
• W3215258178 cites W2886980981 @default.
• W3215258178 cites W2888408613 @default.
• W3215258178 cites W2889646458 @default.
• W3215258178 cites W2895985564 @default.
• W3215258178 cites W2896872272 @default.
• W3215258178 cites W2899919809 @default.
• W3215258178 cites W2901026820 @default.
• W3215258178 cites W2911188335 @default.
• W3215258178 cites W2927467103 @default.
• W3215258178 cites W2938629106 @default.
• W3215258178 cites W2952752961 @default.
• W3215258178 cites W2971584512 @default.
• W3215258178 cites W2973744345 @default.
• W3215258178 cites W2990630271 @default.
• W3215258178 cites W3008266283 @default.
• W3215258178 cites W3016646112 @default.
• W3215258178 cites W3048518217 @default.
• W3215258178 cites W3086246494 @default.
• W3215258178 cites W3118871558 @default.
• W3215258178 cites W3133670891 @default.
• W3215258178 cites W4248025115 @default.
• W3215258178 cites W4254687493 @default.
• W3215258178 cites W3146385010 @default.
• W3215258178 doi "https://doi.org/10.1186/s12885-021-09006-w" @default.
• W3215258178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8611960" @default.
• W3215258178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34819038" @default.
• W3215258178 hasPublicationYear "2021" @default.
• W3215258178 type Work @default.
• W3215258178 sameAs 3215258178 @default.
• W3215258178 citedByCount "6" @default.
• W3215258178 countsByYear W32152581782022 @default.
• W3215258178 countsByYear W32152581782023 @default.
• W3215258178 crossrefType "journal-article" @default.
• W3215258178 hasAuthorship W3215258178A5001129223 @default.
• W3215258178 hasAuthorship W3215258178A5006100271 @default.
• W3215258178 hasAuthorship W3215258178A5033131479 @default.
• W3215258178 hasAuthorship W3215258178A5037967253 @default.
• W3215258178 hasAuthorship W3215258178A5043069455 @default.
• W3215258178 hasAuthorship W3215258178A5078845886 @default.
• W3215258178 hasBestOaLocation W32152581781 @default.
• W3215258178 hasConcept C104317684 @default.
• W3215258178 hasConcept C10515644 @default.
• W3215258178 hasConcept C119857082 @default.
• W3215258178 hasConcept C121608353 @default.
• W3215258178 hasConcept C126322002 @default.
• W3215258178 hasConcept C143998085 @default.
• W3215258178 hasConcept C150194340 @default.
• W3215258178 hasConcept C161584116 @default.
• W3215258178 hasConcept C199163554 @default.

• next