FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215270815> ?p ?o ?g. }

• W3215270815 abstract "Allergic conjunctivitis (AC) is the most prevalent form of mucosal allergy, and the conditioned medium (CM) from mesenchymal stem cells has been reported to attenuate some allergic diseases. However, the therapeutic effects of CM from different tissue stem cells (TSC-CM) on allergic diseases have not been tested. Here, we studied the effects of topical administration of different human TSC-CM on experimental AC (EAC) mice. Only human amniotic epithelial cell-CM (AECM) significantly attenuated allergic eye symptoms and reduced the infiltration of immune cells and the levels of local inflammatory factors in the conjunctiva compared to EAC mice. In addition, AECM treatment decreased immunoglobulin E (IgE) release, histamine production, and the hyperpermeability of conjunctival vessels. Protein chip assays revealed that the levels of anti-inflammatory factors, interleukin-1 receptor antagonist (IL-1ra) and IL-10, were higher in AECM compared to other TSC-CM. Furthermore, the anti-allergic effects of AECM on EAC mice were abrogated when neutralized with IL-1ra or IL-10 antibody, and the similar phenomenon was for the activation and function of B cells and mast cells. Together, the present study demonstrated that AECM alleviates EAC symptoms by multiple anti-allergic mechanisms mainly via IL-1ra and IL-10. Such topical AECM therapy may represent a novel and feasible strategy for treating AC." @default.
• W3215270815 created "2021-12-06" @default.
• W3215270815 creator A5030579237 @default.
• W3215270815 creator A5051230431 @default.
• W3215270815 creator A5054162428 @default.
• W3215270815 creator A5059304852 @default.
• W3215270815 creator A5083353873 @default.
• W3215270815 creator A5087419694 @default.
• W3215270815 date "2021-11-22" @default.
• W3215270815 modified "2023-10-03" @default.
• W3215270815 title "Conditioned Medium of Human Amniotic Epithelial Cells Alleviates Experimental Allergic Conjunctivitis Mainly by IL-1ra and IL-10" @default.
• W3215270815 cites W1482145361 @default.
• W3215270815 cites W1560264230 @default.
• W3215270815 cites W1586272693 @default.
• W3215270815 cites W1600024584 @default.
• W3215270815 cites W1604429956 @default.
• W3215270815 cites W1639895894 @default.
• W3215270815 cites W1717743938 @default.
• W3215270815 cites W1839301559 @default.
• W3215270815 cites W1917157987 @default.
• W3215270815 cites W193075665 @default.
• W3215270815 cites W1970892084 @default.
• W3215270815 cites W1980594957 @default.
• W3215270815 cites W1988038423 @default.
• W3215270815 cites W1998308940 @default.
• W3215270815 cites W2001748248 @default.
• W3215270815 cites W2004510831 @default.
• W3215270815 cites W2006107958 @default.
• W3215270815 cites W2007589345 @default.
• W3215270815 cites W2014726074 @default.
• W3215270815 cites W2023995274 @default.
• W3215270815 cites W2035695611 @default.
• W3215270815 cites W2041189489 @default.
• W3215270815 cites W2042487476 @default.
• W3215270815 cites W2045544714 @default.
• W3215270815 cites W2048819894 @default.
• W3215270815 cites W2052122855 @default.
• W3215270815 cites W2060603072 @default.
• W3215270815 cites W2062010796 @default.
• W3215270815 cites W2075275458 @default.
• W3215270815 cites W2078633109 @default.
• W3215270815 cites W2082909405 @default.
• W3215270815 cites W2109274354 @default.
• W3215270815 cites W2114123652 @default.
• W3215270815 cites W2115385213 @default.
• W3215270815 cites W2134720588 @default.
• W3215270815 cites W2139297286 @default.
• W3215270815 cites W2155510706 @default.
• W3215270815 cites W2156558003 @default.
• W3215270815 cites W2165044128 @default.
• W3215270815 cites W2168208051 @default.
• W3215270815 cites W2185333371 @default.
• W3215270815 cites W2313289314 @default.
• W3215270815 cites W2399763054 @default.
• W3215270815 cites W2508710172 @default.
• W3215270815 cites W2522407676 @default.
• W3215270815 cites W2601218642 @default.
• W3215270815 cites W2605936829 @default.
• W3215270815 cites W2614031938 @default.
• W3215270815 cites W2623996578 @default.
• W3215270815 cites W2756993541 @default.
• W3215270815 cites W2780744144 @default.
• W3215270815 cites W2791630509 @default.
• W3215270815 cites W2792580051 @default.
• W3215270815 cites W2804329563 @default.
• W3215270815 cites W2887526850 @default.
• W3215270815 cites W2894513274 @default.
• W3215270815 cites W2911145283 @default.
• W3215270815 cites W2922671334 @default.
• W3215270815 cites W2924498989 @default.
• W3215270815 cites W2942270140 @default.
• W3215270815 cites W2946100233 @default.
• W3215270815 cites W2953911840 @default.
• W3215270815 cites W2969585060 @default.
• W3215270815 cites W2972466681 @default.
• W3215270815 cites W2981836840 @default.
• W3215270815 cites W2990418437 @default.
• W3215270815 cites W2991358993 @default.
• W3215270815 cites W3017243701 @default.
• W3215270815 doi "https://doi.org/10.3389/fimmu.2021.774601" @default.
• W3215270815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34880869" @default.
• W3215270815 hasPublicationYear "2021" @default.
• W3215270815 type Work @default.
• W3215270815 sameAs 3215270815 @default.
• W3215270815 citedByCount "5" @default.
• W3215270815 countsByYear W32152708152022 @default.
• W3215270815 countsByYear W32152708152023 @default.
• W3215270815 crossrefType "journal-article" @default.
• W3215270815 hasAuthorship W3215270815A5030579237 @default.
• W3215270815 hasAuthorship W3215270815A5051230431 @default.
• W3215270815 hasAuthorship W3215270815A5054162428 @default.
• W3215270815 hasAuthorship W3215270815A5059304852 @default.
• W3215270815 hasAuthorship W3215270815A5083353873 @default.
• W3215270815 hasAuthorship W3215270815A5087419694 @default.
• W3215270815 hasBestOaLocation W32152708151 @default.
• W3215270815 hasConcept C1122143 @default.
• W3215270815 hasConcept C141105273 @default.
• W3215270815 hasConcept C142724271 @default.
• W3215270815 hasConcept C159654299 @default.
• W3215270815 hasConcept C172680121 @default.

• next