FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215340936> ?p ?o ?g. }

• W3215340936 endingPage "121314" @default.
• W3215340936 startingPage "121314" @default.
• W3215340936 abstract "mRNA based gene therapies hold the potential to treat multiple diseases with significant advantages over DNA based therapies, including rapid protein expression and minimized risk of mutagenesis. However, successful delivery of mRNA remains challenging, and clinical translation of mRNA therapeutics has been limited. This study investigated the use of a lipid/polymer hybrid (LPH) nanocarrier for mRNA, designed to address key delivery challenges and shuttle mRNA to targeted tissues. LPH nanocarriers were synthesized using a scalable microfluidic process with a variety of material compositions and mRNA loading strategies. Results show that a combination of permanently ionized and transiently, pH-dependent ionizable cationic lipids had a synergistic effect upon on mRNA gene translation, when compared to each lipid independently. Upon intravenous administration, particles with adsorbed mRNA outperformed particles with encapsulated mRNA for protein expression in the lungs and the spleen despite significant LPH nanoparticle localization to the liver. In contrast, encapsulated particles had higher localized expression when injected intramuscularly with protein expression detectable out to 12 days post injection. Intramuscular administration of particles with OVA mRNA resulted in robust humoral immune response with encapsulated outperforming adsorbed particles in terms of antibody titers at 28 days. These results demonstrate LPH nanocarriers have great potential as a vehicle for mRNA delivery and expression in tissues and that tissue expression and longevity can be influenced by LPH composition and route of administration." @default.
• W3215340936 created "2021-12-06" @default.
• W3215340936 creator A5001164276 @default.
• W3215340936 creator A5014825212 @default.
• W3215340936 creator A5014969889 @default.
• W3215340936 creator A5033628003 @default.
• W3215340936 creator A5053605155 @default.
• W3215340936 date "2022-01-01" @default.
• W3215340936 modified "2023-10-01" @default.
• W3215340936 title "A scalable and robust cationic lipid/polymer hybrid nanoparticle platform for mRNA delivery" @default.
• W3215340936 cites W1420726270 @default.
• W3215340936 cites W1585872414 @default.
• W3215340936 cites W1667670121 @default.
• W3215340936 cites W1945220000 @default.
• W3215340936 cites W1965174032 @default.
• W3215340936 cites W1974314236 @default.
• W3215340936 cites W1981552958 @default.
• W3215340936 cites W2029397995 @default.
• W3215340936 cites W2032517146 @default.
• W3215340936 cites W2051758698 @default.
• W3215340936 cites W2054569703 @default.
• W3215340936 cites W2106885643 @default.
• W3215340936 cites W2139511604 @default.
• W3215340936 cites W2143743183 @default.
• W3215340936 cites W2152119053 @default.
• W3215340936 cites W2164285516 @default.
• W3215340936 cites W2249755146 @default.
• W3215340936 cites W2412158473 @default.
• W3215340936 cites W2525553968 @default.
• W3215340936 cites W2570278065 @default.
• W3215340936 cites W2573033399 @default.
• W3215340936 cites W2584249987 @default.
• W3215340936 cites W2587871737 @default.
• W3215340936 cites W2630192492 @default.
• W3215340936 cites W2725326379 @default.
• W3215340936 cites W2748490245 @default.
• W3215340936 cites W2754401101 @default.
• W3215340936 cites W2761050500 @default.
• W3215340936 cites W2782708334 @default.
• W3215340936 cites W2788471465 @default.
• W3215340936 cites W2806494694 @default.
• W3215340936 cites W2885485598 @default.
• W3215340936 cites W2890153875 @default.
• W3215340936 cites W2890559446 @default.
• W3215340936 cites W2891634798 @default.
• W3215340936 cites W2900639711 @default.
• W3215340936 cites W2903347779 @default.
• W3215340936 cites W2915308412 @default.
• W3215340936 cites W2969814123 @default.
• W3215340936 cites W3015140168 @default.
• W3215340936 cites W3086192834 @default.
• W3215340936 cites W3089495849 @default.
• W3215340936 cites W4205483821 @default.
• W3215340936 doi "https://doi.org/10.1016/j.ijpharm.2021.121314" @default.
• W3215340936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34838950" @default.
• W3215340936 hasPublicationYear "2022" @default.
• W3215340936 type Work @default.
• W3215340936 sameAs 3215340936 @default.
• W3215340936 citedByCount "9" @default.
• W3215340936 countsByYear W32153409362022 @default.
• W3215340936 countsByYear W32153409362023 @default.
• W3215340936 crossrefType "journal-article" @default.
• W3215340936 hasAuthorship W3215340936A5001164276 @default.
• W3215340936 hasAuthorship W3215340936A5014825212 @default.
• W3215340936 hasAuthorship W3215340936A5014969889 @default.
• W3215340936 hasAuthorship W3215340936A5033628003 @default.
• W3215340936 hasAuthorship W3215340936A5053605155 @default.
• W3215340936 hasConcept C104317684 @default.
• W3215340936 hasConcept C105580179 @default.
• W3215340936 hasConcept C111599444 @default.
• W3215340936 hasConcept C135983454 @default.
• W3215340936 hasConcept C149364088 @default.
• W3215340936 hasConcept C150194340 @default.
• W3215340936 hasConcept C153911025 @default.
• W3215340936 hasConcept C178790620 @default.
• W3215340936 hasConcept C18150654 @default.
• W3215340936 hasConcept C185592680 @default.
• W3215340936 hasConcept C2779820397 @default.
• W3215340936 hasConcept C55493867 @default.
• W3215340936 hasConcept C86803240 @default.
• W3215340936 hasConcept C95444343 @default.
• W3215340936 hasConceptScore W3215340936C104317684 @default.
• W3215340936 hasConceptScore W3215340936C105580179 @default.
• W3215340936 hasConceptScore W3215340936C111599444 @default.
• W3215340936 hasConceptScore W3215340936C135983454 @default.
• W3215340936 hasConceptScore W3215340936C149364088 @default.
• W3215340936 hasConceptScore W3215340936C150194340 @default.
• W3215340936 hasConceptScore W3215340936C153911025 @default.
• W3215340936 hasConceptScore W3215340936C178790620 @default.
• W3215340936 hasConceptScore W3215340936C18150654 @default.
• W3215340936 hasConceptScore W3215340936C185592680 @default.
• W3215340936 hasConceptScore W3215340936C2779820397 @default.
• W3215340936 hasConceptScore W3215340936C55493867 @default.
• W3215340936 hasConceptScore W3215340936C86803240 @default.
• W3215340936 hasConceptScore W3215340936C95444343 @default.
• W3215340936 hasLocation W32153409361 @default.
• W3215340936 hasLocation W32153409362 @default.
• W3215340936 hasOpenAccess W3215340936 @default.

• next