Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215348528> ?p ?o ?g. }
- W3215348528 endingPage "213" @default.
- W3215348528 startingPage "206" @default.
- W3215348528 abstract "Ginsenoside Rb2 is an active protopanaxadiol-type saponin, widely existing in the stem and leave of ginseng. Rb2 has recently been the focus of studies for pharmaceutical properties. This paper provides an overview of the preclinical and clinical pharmacokinetics for Rb2, which exhibit poor absorption, rapid tissue distribution and slow excretion through urine. Pharmacological studies indicate a beneficial role of Rb2 in the prevention and treatment of diabetes, obesity, tumor, photoaging, virus infection and cardiovascular problems. The underlying mechanism is involved in an inhibition of oxidative stress, ROS generation, inflammation and apoptosis via regulation of various cellular signaling pathways and molecules, including AKT/SHP, MAPK, EGFR/SOX2, TGF-β1/Smad, SIRT1, GPR120/AMPK/HO-1 and NF-κB. This work would provide a new insight into the understanding and application of Rb2. However, its therapeutic effects have not been clinically evaluated. Further studies should be aimed at the clinical treatment of Rb2." @default.
- W3215348528 created "2021-12-06" @default.
- W3215348528 creator A5028343495 @default.
- W3215348528 creator A5046685277 @default.
- W3215348528 creator A5069694896 @default.
- W3215348528 creator A5071991352 @default.
- W3215348528 creator A5072041654 @default.
- W3215348528 creator A5082472698 @default.
- W3215348528 date "2022-03-01" @default.
- W3215348528 modified "2023-10-18" @default.
- W3215348528 title "Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects" @default.
- W3215348528 cites W1571775679 @default.
- W3215348528 cites W1577169337 @default.
- W3215348528 cites W1605831262 @default.
- W3215348528 cites W1931918221 @default.
- W3215348528 cites W1973406117 @default.
- W3215348528 cites W1982420531 @default.
- W3215348528 cites W1984839458 @default.
- W3215348528 cites W1988810371 @default.
- W3215348528 cites W1990797116 @default.
- W3215348528 cites W1998997045 @default.
- W3215348528 cites W2001947328 @default.
- W3215348528 cites W2001962823 @default.
- W3215348528 cites W2002475509 @default.
- W3215348528 cites W2012037560 @default.
- W3215348528 cites W2015485624 @default.
- W3215348528 cites W2017619156 @default.
- W3215348528 cites W2029364484 @default.
- W3215348528 cites W2041510403 @default.
- W3215348528 cites W2045576550 @default.
- W3215348528 cites W2046034976 @default.
- W3215348528 cites W2051726726 @default.
- W3215348528 cites W2060004662 @default.
- W3215348528 cites W2065039243 @default.
- W3215348528 cites W2082742818 @default.
- W3215348528 cites W2085804112 @default.
- W3215348528 cites W2110413597 @default.
- W3215348528 cites W2118727180 @default.
- W3215348528 cites W2127348856 @default.
- W3215348528 cites W2134265995 @default.
- W3215348528 cites W2135314348 @default.
- W3215348528 cites W2158919281 @default.
- W3215348528 cites W2194227846 @default.
- W3215348528 cites W2205521896 @default.
- W3215348528 cites W2211557888 @default.
- W3215348528 cites W2256100430 @default.
- W3215348528 cites W2281849840 @default.
- W3215348528 cites W2302464372 @default.
- W3215348528 cites W2412680253 @default.
- W3215348528 cites W2516543055 @default.
- W3215348528 cites W2549727572 @default.
- W3215348528 cites W2565198235 @default.
- W3215348528 cites W2568174096 @default.
- W3215348528 cites W2604037976 @default.
- W3215348528 cites W2614783385 @default.
- W3215348528 cites W2623447472 @default.
- W3215348528 cites W2733655467 @default.
- W3215348528 cites W2768554704 @default.
- W3215348528 cites W2772490526 @default.
- W3215348528 cites W2779317138 @default.
- W3215348528 cites W2785616396 @default.
- W3215348528 cites W2789605138 @default.
- W3215348528 cites W2790517371 @default.
- W3215348528 cites W2791488154 @default.
- W3215348528 cites W2795067285 @default.
- W3215348528 cites W2810751642 @default.
- W3215348528 cites W2884514295 @default.
- W3215348528 cites W2893324863 @default.
- W3215348528 cites W2897408819 @default.
- W3215348528 cites W2898339719 @default.
- W3215348528 cites W2904108713 @default.
- W3215348528 cites W2907927100 @default.
- W3215348528 cites W2920961192 @default.
- W3215348528 cites W2948614113 @default.
- W3215348528 cites W2961216675 @default.
- W3215348528 cites W2970766058 @default.
- W3215348528 cites W2985121700 @default.
- W3215348528 cites W2989900534 @default.
- W3215348528 cites W3003871410 @default.
- W3215348528 cites W3027789105 @default.
- W3215348528 cites W3038015396 @default.
- W3215348528 cites W3042189474 @default.
- W3215348528 cites W3045607826 @default.
- W3215348528 cites W3092740337 @default.
- W3215348528 cites W3172566697 @default.
- W3215348528 doi "https://doi.org/10.1016/j.jgr.2021.11.007" @default.
- W3215348528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35509822" @default.
- W3215348528 hasPublicationYear "2022" @default.
- W3215348528 type Work @default.
- W3215348528 sameAs 3215348528 @default.
- W3215348528 citedByCount "13" @default.
- W3215348528 countsByYear W32153485282022 @default.
- W3215348528 countsByYear W32153485282023 @default.
- W3215348528 crossrefType "journal-article" @default.
- W3215348528 hasAuthorship W3215348528A5028343495 @default.
- W3215348528 hasAuthorship W3215348528A5046685277 @default.
- W3215348528 hasAuthorship W3215348528A5069694896 @default.
- W3215348528 hasAuthorship W3215348528A5071991352 @default.