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- W3215395415 endingPage "17672" @default.
- W3215395415 startingPage "17667" @default.
- W3215395415 abstract "Peptide drugs bradykinin, a leuprolide analogue, 2(PZ-128), and rapastinel are synthesized in 56-77% yield using heating-assisted liquid-phase peptide synthesis on a soluble polynorbornene support. These drugs of commercial utility and complex structures are obtained in 2-5.5 h with no epimerization and >95% purity using only 1.2 equivalents of amino acids and coupling reagents. The peptide yield and purity are comparable or superior to the reported methods." @default.
- W3215395415 created "2021-12-06" @default.
- W3215395415 creator A5024334738 @default.
- W3215395415 creator A5078262287 @default.
- W3215395415 date "2021-11-25" @default.
- W3215395415 modified "2023-09-27" @default.
- W3215395415 title "Quick Access to High-Purity Peptide Drugs Bradykinin, Leuprolide Analogue, 2(PZ-128), and Rapastinel with Minimal Reagents" @default.
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- W3215395415 doi "https://doi.org/10.1021/acs.joc.1c01906" @default.
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