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- W3215396884 endingPage "12958" @default.
- W3215396884 startingPage "12958" @default.
- W3215396884 abstract "Peptides inherently feature the favorable properties of being easily synthesized, water-soluble, biocompatible, and typically non-toxic. Thus, boronic acid has been widely integrated with peptides with the goal of discovering peptide ligands with novel biological activities, and this effort has led to broad applications. Taking the integration between boronic acid and peptide as a starting point, we provide an overview of the latest research advances and highlight the versatile and robust functionalities of boronic acid. In this review, we summarize the diverse applications of peptide boronic acids in medicinal chemistry and chemical biology, including the identification of covalent reversible enzyme inhibitors, recognition, and detection of glycans on proteins or cancer cell surface, delivery of siRNAs, development of pH responsive devices, and recognition of RNA or bacterial surfaces. Additionally, we discuss boronic acid-mediated peptide cyclization and peptide modifications, as well as the facile chemical synthesis of peptide boronic acids, which paved the way for developing a growing number of peptide boronic acids." @default.
- W3215396884 created "2021-12-06" @default.
- W3215396884 creator A5006923891 @default.
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- W3215396884 creator A5084233348 @default.
- W3215396884 date "2021-11-30" @default.
- W3215396884 modified "2023-09-29" @default.
- W3215396884 title "Merging the Versatile Functionalities of Boronic Acid with Peptides" @default.
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