FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215405280> ?p ?o ?g. }

• W3215405280 endingPage "148" @default.
• W3215405280 startingPage "146" @default.
• W3215405280 abstract "A 61-year-old man sought care for recurrent episodes of dysarthria for about 1 year. This symptom was more common after prolonged speaking. Six months before his evaluation he had significant slurring of his speech after talking for 3½ hours at work about a new project. This led to emergency evaluation and his symptoms were thought to represent a transient ischemic attack; he started aspirin and a statin. The episodes continued to recur. He also experienced intermittent binocular double vision, which did not improve with new eyeglasses, and a sensation that chewing and swallowing was more effortful. He noted that his arms and legs felt “heavy” at times. All these symptoms tended to occur later in the day or after exertion. Neurologic examination was remarkable for binocular double vision with prolonged gaze upward or to the far right. He could squat and rise 5 times but with difficulty by the 5th attempt. The patient’s symptoms suggested myasthenia gravis. The differential diagnosis for autoimmune myasthenia gravis, particularly with prominent ocular and facial muscle involvement, can include central nervous system disorders, motor neuron disease, and myopathy. Serologic evaluation showed positivity for acetylcholine receptor-binding antibody and acetylcholine receptor-modulating antibody. Striated muscle antibody was also positive. Thiopurine S-methyltransferase activity was low. Repetitive stimulation studies showed a decrement in the right facial nerve, which partially improved after exercise. Routine needle examination showed motor unit variation in the right orbicularis oculi. Single-fiber electromyography showed increased jitter in the right orbicularis oculi. Chest computed tomography showed scattered tiny pulmonary nodules but no evidence of thymoma or other neoplasm. The clinical diagnosis was autoimmune generalized myasthenia gravis, seropositive for acetylcholine receptor antibody, without evident thymoma or other neoplasm. The patient was initially treated with oral pyridostigmine with some symptomatic benefit. Oral prednisone was then initiated; symptoms resolved when the dose was titrated. Calcium and vitamin D supplements, as well as <italic>Pneumocystis</italic> prophylactic therapy, were initiated concurrently. Mycophenolate mofetil was added as a steroid-sparing agent. On thoracic surgery consultation, thymectomy was recommended. Autoimmune myasthenia gravis is a disorder of impaired neuromuscular transmission caused by immunoglobulin G-mediated attack on a critical component of the acetylcholine receptor signaling complex in the muscle’s postsynaptic membrane. The most commonly identified antibodies, target the nicotinic acetylcholine receptor." @default.
• W3215405280 created "2021-12-06" @default.
• W3215405280 creator A5018483789 @default.
• W3215405280 creator A5055122406 @default.
• W3215405280 date "2021-11-01" @default.
• W3215405280 modified "2023-09-24" @default.
• W3215405280 title "Bulbar-Predominant Weakness" @default.
• W3215405280 doi "https://doi.org/10.1093/med/9780197583425.003.0047" @default.
• W3215405280 hasPublicationYear "2021" @default.
• W3215405280 type Work @default.
• W3215405280 sameAs 3215405280 @default.
• W3215405280 citedByCount "0" @default.
• W3215405280 crossrefType "book-chapter" @default.
• W3215405280 hasAuthorship W3215405280A5018483789 @default.
• W3215405280 hasAuthorship W3215405280A5055122406 @default.
• W3215405280 hasConcept C126322002 @default.
• W3215405280 hasConcept C141071460 @default.
• W3215405280 hasConcept C164705383 @default.
• W3215405280 hasConcept C2777515770 @default.
• W3215405280 hasConcept C2778105408 @default.
• W3215405280 hasConcept C2780156709 @default.
• W3215405280 hasConcept C2780168130 @default.
• W3215405280 hasConcept C2780247198 @default.
• W3215405280 hasConcept C42219234 @default.
• W3215405280 hasConcept C71924100 @default.
• W3215405280 hasConcept C99508421 @default.
• W3215405280 hasConceptScore W3215405280C126322002 @default.
• W3215405280 hasConceptScore W3215405280C141071460 @default.
• W3215405280 hasConceptScore W3215405280C164705383 @default.
• W3215405280 hasConceptScore W3215405280C2777515770 @default.
• W3215405280 hasConceptScore W3215405280C2778105408 @default.
• W3215405280 hasConceptScore W3215405280C2780156709 @default.
• W3215405280 hasConceptScore W3215405280C2780168130 @default.
• W3215405280 hasConceptScore W3215405280C2780247198 @default.
• W3215405280 hasConceptScore W3215405280C42219234 @default.
• W3215405280 hasConceptScore W3215405280C71924100 @default.
• W3215405280 hasConceptScore W3215405280C99508421 @default.
• W3215405280 hasLocation W32154052801 @default.
• W3215405280 hasOpenAccess W3215405280 @default.
• W3215405280 hasPrimaryLocation W32154052801 @default.
• W3215405280 hasRelatedWork W2005457188 @default.
• W3215405280 hasRelatedWork W2044046099 @default.
• W3215405280 hasRelatedWork W2047564990 @default.
• W3215405280 hasRelatedWork W2077330876 @default.
• W3215405280 hasRelatedWork W2418809142 @default.
• W3215405280 hasRelatedWork W2431066876 @default.
• W3215405280 hasRelatedWork W2886826388 @default.
• W3215405280 hasRelatedWork W2988682959 @default.
• W3215405280 hasRelatedWork W2994690975 @default.
• W3215405280 hasRelatedWork W4313546246 @default.
• W3215405280 isParatext "false" @default.
• W3215405280 isRetracted "false" @default.
• W3215405280 magId "3215405280" @default.
• W3215405280 workType "book-chapter" @default.