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- W3215442912 endingPage "18974" @default.
- W3215442912 startingPage "18964" @default.
- W3215442912 abstract "The synthesis, chemical and biological characterization of seven Ru(II) polypyridyl complexes containing acetylacetonate (acac) ligands are reported. Electronic absorption spectra were determined and electrochemical potentials consistent with Ru(III/II) couples ranging from +0.60 to +0.73 V vs Ag/AgCl were measured. A series of complexes were screened against MDA-MB-231, DU-145, and MCF-10A cell lines to evaluate their cytotoxicities in cancer and normal cell lines. Although most complexes were either nontoxic or equipotent in cancer cells and normal cell lines, compound 1, [Ru(dpqy)(acac)(py)](PF6), where dqpy is 2,6-di(quinolin-2-yl)pyridine, showed up to 2.5:1.0 selectivity for cancer as compared to normal cells, along with nanomolar EC50 values in MDA-MB-231 cells. Lipophilicity, determined as the octanol/water partition coefficient, log Po/w, ranged from -0.33 (0.06) to 1.15 (0.10) for the complexes. Although cytotoxicity was not correlated with electrochemical potentials, a moderate linear correlation between lipophilicity and toxicities was observed. Cell death mechanism studies indicated that several of the Ru-acac compounds, including 1, induce apoptosis in MDA-MB-231 cells." @default.
- W3215442912 created "2021-12-06" @default.
- W3215442912 creator A5017389225 @default.
- W3215442912 creator A5017416631 @default.
- W3215442912 creator A5022218008 @default.
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- W3215442912 creator A5038676358 @default.
- W3215442912 creator A5039803963 @default.
- W3215442912 creator A5078616211 @default.
- W3215442912 creator A5081698620 @default.
- W3215442912 date "2021-11-30" @default.
- W3215442912 modified "2023-10-16" @default.
- W3215442912 title "Ru(II)-Based Acetylacetonate Complexes Induce Apoptosis Selectively in Cancer Cells" @default.
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- W3215442912 doi "https://doi.org/10.1021/acs.inorgchem.1c02796" @default.