Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215474302> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3215474302 endingPage "122" @default.
- W3215474302 startingPage "111" @default.
- W3215474302 abstract "Lianhuaqingwen (LH) is the widely used in the treatment of Coronavirus disease 2019 (COVID-19). However, its mechanisms of action and molecular targets for treatment of COVID-19 are not clear. The active compounds of LH were collected and their targets were identified through the network pharmacology. The mechanism of compound multi components and multi targets and its relationship with disease are analyzed. COVID-19 targets were obtained by analyzing with TCMSP. In total, 282 active ingredients and 510 targets of LH were identified. Twenty-one target genes associated with LH and COVID-19. Protein-protein interaction (PPI) data were then obtained and PPI networks of LH putative targets and COVID-19-related targets were visualized and merged to identify the candidate targets for LH against COVID-19. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis were carried out. The gene-pathway network was constructed to screen the crucial target genes. The functional annotations of target genes were found to be related to immune regulation, host defense, inflammatory reaction and autoimmune diseases and so on. Twenty pathways including immunology, cancer, and cell processing were significantly enriched. Quercetin and luteolin might be the crucial ingredients. IL6 was the core gene and other several genes including IL1B, STAT1, IFNGR1, and NCF1 were the key genes in the gene-pathway network of LH for treatment of COVID-19. The results indicated that LH’s effects against COVID-19 might relate to regulation of immunological function through the specific biological processes and the related pathways. This study demonstrates the application of network pharmacology in evaluating mechanisms of action and molecular targets of complex herbal formulations." @default.
- W3215474302 created "2021-12-06" @default.
- W3215474302 creator A5022405722 @default.
- W3215474302 creator A5042940302 @default.
- W3215474302 creator A5072190113 @default.
- W3215474302 creator A5083722375 @default.
- W3215474302 creator A5088407577 @default.
- W3215474302 date "2021-11-24" @default.
- W3215474302 modified "2023-10-03" @default.
- W3215474302 title "Elucidation of the Mechanisms and Molecular Targets of Lianhuaqingwen for Treatment of COVID-19 Based on Network Pharmacology" @default.
- W3215474302 doi "https://doi.org/10.53043/2347-3894.acam90020" @default.
- W3215474302 hasPublicationYear "2021" @default.
- W3215474302 type Work @default.
- W3215474302 sameAs 3215474302 @default.
- W3215474302 citedByCount "0" @default.
- W3215474302 crossrefType "journal-article" @default.
- W3215474302 hasAuthorship W3215474302A5022405722 @default.
- W3215474302 hasAuthorship W3215474302A5042940302 @default.
- W3215474302 hasAuthorship W3215474302A5072190113 @default.
- W3215474302 hasAuthorship W3215474302A5083722375 @default.
- W3215474302 hasAuthorship W3215474302A5088407577 @default.
- W3215474302 hasBestOaLocation W32154743021 @default.
- W3215474302 hasConcept C104317684 @default.
- W3215474302 hasConcept C141231307 @default.
- W3215474302 hasConcept C142724271 @default.
- W3215474302 hasConcept C150194340 @default.
- W3215474302 hasConcept C152724338 @default.
- W3215474302 hasConcept C2779134260 @default.
- W3215474302 hasConcept C2987395477 @default.
- W3215474302 hasConcept C3008058167 @default.
- W3215474302 hasConcept C524204448 @default.
- W3215474302 hasConcept C54355233 @default.
- W3215474302 hasConcept C67339327 @default.
- W3215474302 hasConcept C70721500 @default.
- W3215474302 hasConcept C71924100 @default.
- W3215474302 hasConcept C86803240 @default.
- W3215474302 hasConceptScore W3215474302C104317684 @default.
- W3215474302 hasConceptScore W3215474302C141231307 @default.
- W3215474302 hasConceptScore W3215474302C142724271 @default.
- W3215474302 hasConceptScore W3215474302C150194340 @default.
- W3215474302 hasConceptScore W3215474302C152724338 @default.
- W3215474302 hasConceptScore W3215474302C2779134260 @default.
- W3215474302 hasConceptScore W3215474302C2987395477 @default.
- W3215474302 hasConceptScore W3215474302C3008058167 @default.
- W3215474302 hasConceptScore W3215474302C524204448 @default.
- W3215474302 hasConceptScore W3215474302C54355233 @default.
- W3215474302 hasConceptScore W3215474302C67339327 @default.
- W3215474302 hasConceptScore W3215474302C70721500 @default.
- W3215474302 hasConceptScore W3215474302C71924100 @default.
- W3215474302 hasConceptScore W3215474302C86803240 @default.
- W3215474302 hasIssue "4" @default.
- W3215474302 hasLocation W32154743021 @default.
- W3215474302 hasOpenAccess W3215474302 @default.
- W3215474302 hasPrimaryLocation W32154743021 @default.
- W3215474302 hasRelatedWork W1603543036 @default.
- W3215474302 hasRelatedWork W2069184423 @default.
- W3215474302 hasRelatedWork W2909382709 @default.
- W3215474302 hasRelatedWork W2916366426 @default.
- W3215474302 hasRelatedWork W2994628499 @default.
- W3215474302 hasRelatedWork W3172058479 @default.
- W3215474302 hasRelatedWork W3175754231 @default.
- W3215474302 hasRelatedWork W4281868569 @default.
- W3215474302 hasRelatedWork W4307027640 @default.
- W3215474302 hasRelatedWork W2187207551 @default.
- W3215474302 hasVolume "9" @default.
- W3215474302 isParatext "false" @default.
- W3215474302 isRetracted "false" @default.
- W3215474302 magId "3215474302" @default.
- W3215474302 workType "article" @default.