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• W3215493172 abstract "Human natural killer (NK) and innate lymphoid cells (ILCs) include diverse specialized phenotypic and functional subsets that reflect their roles as innate immune effector cells present in tissue and circulation. In recent years, significant advances have been made in better defining their tissue resident phenotypes, developmental pathways, and phenotypic plasticity. Here we offer a brief review of new insights into human NK cell diversity specifically defined by next generation sequencing and single-cell transcriptomic studies and integrate these into our current models of human NK cell developmental trajectories and mature subsets. These studies highlight both a deeper understanding of innate lymphoid cell differentiation and homeostasis and underscore critical questions that remain outstanding in the field." @default.
• W3215493172 created "2021-12-06" @default.
• W3215493172 creator A5014965298 @default.
• W3215493172 creator A5016163533 @default.
• W3215493172 date "2022-02-01" @default.
• W3215493172 modified "2023-09-26" @default.
• W3215493172 title "Diversity of human NK cell developmental pathways defined by single-cell analyses" @default.
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• W3215493172 doi "https://doi.org/10.1016/j.coi.2021.11.001" @default.
• W3215493172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34861544" @default.
• W3215493172 hasPublicationYear "2022" @default.
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