FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215520010> ?p ?o ?g. }

• W3215520010 endingPage "1377" @default.
• W3215520010 startingPage "1377" @default.
• W3215520010 abstract "We evaluated the clinical protection of BNT162b2 mRNA vaccine in healthcare workers (HCWs) and how COVID-19 manifestations and contagiousness change as the time since first dose increases. A matched (1:2 ratio) parallel cohort study was performed. During the first three months of vaccination campaign, HCWs of the entire health district ASL Città di Torino (Turin, Italy) were classified according to SARS-CoV-2-positivity in respect of the vaccination schedule: post-first-dose (fHCWs, <12 days), partially (PHCWs, ≥12 from first dose to ≤7 days after the second), and totally vaccinated (THCWs, ≥8 days after the second dose). Age-/sex-matched unvaccinated controls were randomly selected from all the SARS-CoV-2-positivity detected in the same district and period. Previous infections were excluded. Clinical and virologic data (ORF1ab gene cycle threshold values, Ct) were recorded. In total, 6800 HCWs received at least one dose, and 55 tested positive subsequently: 20 fHCWs, 25 PHCWs, 10 THCWs. Furthermore, 21.8% of breakthrough infections were in male, with a median age of 49 years (32-56), and 51.4% occurred while SARS-CoV-2 B.1.1.7 variant was predominant. The incident relative risk was 0.13 (0.12-0.15) for PHCWs and 0.06 (0.05-0.07) for THCWs. Compared to controls (n = 110), no difference was observed in fHCWs, while PHCWs and THCWs showed higher prevalence of asymptomatic infections, fewer signs/symptoms with a milder systemic involvement, and significantly higher Ct values (PHCWs 30.3 (24.1-35.5) vs. 22.3 (19.6-30.6), p = 0.023; THCWs 35.0 (31.3-35.9) vs. 22.5 (18.2-30.6), p = 0.024). Duration of symptoms was also shorter in THCWs (5 days (3-6) vs. 9 (7-14), p = 0.028). A linear increase of 3.81 points in Ct values was observed across the groups by vaccination status (p = 0.001) after adjusting for age, sex, comorbidities, and time between COVID-19 onset and swab collection. BNT162b2 decreased the risk of PCR-confirmed infections and severe disease, and was associated with a virologic picture of lesser epidemiologic concern as soon as 12 days after the first vaccine dose." @default.
• W3215520010 created "2021-12-06" @default.
• W3215520010 creator A5021206943 @default.
• W3215520010 creator A5039193151 @default.
• W3215520010 creator A5039293512 @default.
• W3215520010 creator A5048108645 @default.
• W3215520010 creator A5050919587 @default.
• W3215520010 creator A5052366087 @default.
• W3215520010 creator A5061896715 @default.
• W3215520010 creator A5086716031 @default.
• W3215520010 date "2021-11-23" @default.
• W3215520010 modified "2023-10-01" @default.
• W3215520010 title "Clinical Phenotype and Contagiousness of Early Breakthrough SARS-CoV-2 Infections after BNT162b2 COVID-19 mRNA Vaccine: A Parallel Cohort Study in Healthcare Workers" @default.
• W3215520010 cites W3015571324 @default.
• W3215520010 cites W3039679645 @default.
• W3215520010 cites W3045700899 @default.
• W3215520010 cites W3111255098 @default.
• W3215520010 cites W3123561898 @default.
• W3215520010 cites W3128674848 @default.
• W3215520010 cites W3131688063 @default.
• W3215520010 cites W3133128009 @default.
• W3215520010 cites W3135724950 @default.
• W3215520010 cites W3136672274 @default.
• W3215520010 cites W3137310706 @default.
• W3215520010 cites W3138702377 @default.
• W3215520010 cites W3141986261 @default.
• W3215520010 cites W3150351745 @default.
• W3215520010 cites W3150664238 @default.
• W3215520010 cites W3153468502 @default.
• W3215520010 cites W3154363361 @default.
• W3215520010 cites W3154724916 @default.
• W3215520010 cites W3156332711 @default.
• W3215520010 cites W3156886555 @default.
• W3215520010 cites W3157637908 @default.
• W3215520010 cites W3158373340 @default.
• W3215520010 cites W3158706520 @default.
• W3215520010 cites W3161817473 @default.
• W3215520010 cites W3186808655 @default.
• W3215520010 cites W3198522490 @default.
• W3215520010 cites W3210049956 @default.
• W3215520010 doi "https://doi.org/10.3390/vaccines9121377" @default.
• W3215520010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34960123" @default.
• W3215520010 hasPublicationYear "2021" @default.
• W3215520010 type Work @default.
• W3215520010 sameAs 3215520010 @default.
• W3215520010 citedByCount "6" @default.
• W3215520010 countsByYear W32155200102022 @default.
• W3215520010 countsByYear W32155200102023 @default.
• W3215520010 crossrefType "journal-article" @default.
• W3215520010 hasAuthorship W3215520010A5021206943 @default.
• W3215520010 hasAuthorship W3215520010A5039193151 @default.
• W3215520010 hasAuthorship W3215520010A5039293512 @default.
• W3215520010 hasAuthorship W3215520010A5048108645 @default.
• W3215520010 hasAuthorship W3215520010A5050919587 @default.
• W3215520010 hasAuthorship W3215520010A5052366087 @default.
• W3215520010 hasAuthorship W3215520010A5061896715 @default.
• W3215520010 hasAuthorship W3215520010A5086716031 @default.
• W3215520010 hasBestOaLocation W32155200101 @default.
• W3215520010 hasConcept C126322002 @default.
• W3215520010 hasConcept C160735492 @default.
• W3215520010 hasConcept C162324750 @default.
• W3215520010 hasConcept C187212893 @default.
• W3215520010 hasConcept C201903717 @default.
• W3215520010 hasConcept C203014093 @default.
• W3215520010 hasConcept C22070199 @default.
• W3215520010 hasConcept C2777910003 @default.
• W3215520010 hasConcept C2779134260 @default.
• W3215520010 hasConcept C3007834351 @default.
• W3215520010 hasConcept C3008058167 @default.
• W3215520010 hasConcept C50522688 @default.
• W3215520010 hasConcept C524204448 @default.
• W3215520010 hasConcept C71924100 @default.
• W3215520010 hasConcept C72563966 @default.
• W3215520010 hasConceptScore W3215520010C126322002 @default.
• W3215520010 hasConceptScore W3215520010C160735492 @default.
• W3215520010 hasConceptScore W3215520010C162324750 @default.
• W3215520010 hasConceptScore W3215520010C187212893 @default.
• W3215520010 hasConceptScore W3215520010C201903717 @default.
• W3215520010 hasConceptScore W3215520010C203014093 @default.
• W3215520010 hasConceptScore W3215520010C22070199 @default.
• W3215520010 hasConceptScore W3215520010C2777910003 @default.
• W3215520010 hasConceptScore W3215520010C2779134260 @default.
• W3215520010 hasConceptScore W3215520010C3007834351 @default.
• W3215520010 hasConceptScore W3215520010C3008058167 @default.
• W3215520010 hasConceptScore W3215520010C50522688 @default.
• W3215520010 hasConceptScore W3215520010C524204448 @default.
• W3215520010 hasConceptScore W3215520010C71924100 @default.
• W3215520010 hasConceptScore W3215520010C72563966 @default.
• W3215520010 hasIssue "12" @default.
• W3215520010 hasLocation W32155200101 @default.
• W3215520010 hasLocation W32155200102 @default.
• W3215520010 hasLocation W32155200103 @default.
• W3215520010 hasLocation W32155200104 @default.
• W3215520010 hasLocation W32155200105 @default.
• W3215520010 hasOpenAccess W3215520010 @default.
• W3215520010 hasPrimaryLocation W32155200101 @default.
• W3215520010 hasRelatedWork W1980275360 @default.
• W3215520010 hasRelatedWork W2031962861 @default.

• next