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- W3215535977 endingPage "12741" @default.
- W3215535977 startingPage "12741" @default.
- W3215535977 abstract "Preclinical, clinical, and epidemiological studies indicate that vitamin D3 (VD) deficiency is a risk factor for the development of breast cancer. Underlying mechanisms include the ability of calcitriol to induce cell differentiation, inhibit oncogenes expression, and modify different signaling pathways involved in the control of cell proliferation. In addition, calcitriol combined with different kinds of antineoplastic drugs has been demonstrated to enhance their beneficial effects in an additive or synergistic fashion. However, a recognized adjuvant regimen based on calcitriol for treating patients with breast cancer has not yet been fully established. Accordingly, in the present work, we review and discuss the preclinical and clinical studies about the combination of calcitriol with different oncological drugs, aiming to emphasize its main therapeutic benefits and opportunities for the treatment of this pathology." @default.
- W3215535977 created "2021-12-06" @default.
- W3215535977 creator A5008658051 @default.
- W3215535977 creator A5013297189 @default.
- W3215535977 creator A5036141735 @default.
- W3215535977 creator A5085272243 @default.
- W3215535977 date "2021-11-25" @default.
- W3215535977 modified "2023-10-18" @default.
- W3215535977 title "Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update" @default.
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