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• W3215567318 abstract "<b>Introduction:</b> Nitric oxide (NO) plays a role in immune responses to pathogens. Exhaled NO (eNO) is used as a noninvasive biomarker of airway inflammation in older children with asthma. However, the role for eNO in infancy has not been completely ascertained. <b>Aim:</b> To investigate the association between eNO at 6 weeks of age and the incidence of bronchiolitis and respiratory symptoms in the first 12 months of life. <b>Methods:</b> Infants at 6 weeks of age, born to mothers with asthma in pregnancy from the Breathing for Life Trial were assessed to measure eNO using a rapid-response chemiluminescence analyzer (CLD88;EcoMedics) interpolated to an expiratory flow of 50mL/s and normalized using square root (sq). We applied a standardised parent completed questionnaire at 12 months of age to investigate bronchiolitis and symptoms. Associations were investigated by multivariate linear and Poisson regression models. <b>Results:</b> 184 babies had valid eNO measurements at 6 weeks of age, 125 (68%) had data at 12 months of age collected. Higher eNO was associated with less respiratory symptoms during the first weeks of life (n=155, ß-coefficient:–0.62, p=0.028). Babies without an episode of bronchiolitis in the first year of life had significantly higher eNO (3.60 ppb vs 3.11 ppb, p=0.009). Risk incidence of bronchiolitis, wheeze, cold or flu, short-acting beta-agonist use, and recurrent bronchiolitis significantly decreased by 18% to 24% for every increase in sq eNO ppb in multivariate models. <b>Conclusion:</b> Infants with higher eNO levels at 6 weeks of age were significantly less likely to develop bronchiolitis and other respiratory symptoms at 12 months of age. In infancy, higher eNO levels may be a surrogate marker for more effective anti-viral immune responses." @default.
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• W3215567318 date "2021-09-05" @default.
• W3215567318 modified "2023-09-26" @default.
• W3215567318 title "Higher exhaled nitric oxide levels in infancy is associated with less bronchiolitis and fewer adverse respiratory outcomes in the first year of life" @default.
• W3215567318 doi "https://doi.org/10.1183/13993003.congress-2021.pa3069" @default.
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