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- W3215573579 endingPage "12911" @default.
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- W3215573579 abstract "Mixed lineage leukemia 1 (MLL1) is a histone methyltransferase. Kaposi's sarcoma-associated herpesvirus (KSHV) is a leading cause of malignancy in AIDS. KSHV latently infects tumor cells and its genome is decorated with epigenetic marks. Here, we show that KSHV latency-associated nuclear antigen (LANA) recruits MLL1 to viral DNA where it establishes H3K4me3 modifications at the extensive KSHV terminal repeat elements during primary infection. LANA interacts with MLL1 complex members, including WDR5, integrates into the MLL1 complex, and regulates MLL1 activity. We describe the 1.5-Å crystal structure of N-terminal LANA peptide complexed with MLL1 complex member WDR5, which reveals a potential regulatory mechanism. Disruption of MLL1 expression rendered KSHV latency establishment highly deficient. This deficiency was rescued by MLL1 but not by catalytically inactive MLL1. Therefore, MLL1 is LANA regulable and exerts a central role in virus infection. These results suggest broad potential for MLL1 regulation, including by non-host factors." @default.
- W3215573579 created "2021-12-06" @default.
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- W3215573579 date "2021-11-29" @default.
- W3215573579 modified "2023-10-13" @default.
- W3215573579 title "MLL1 is regulated by KSHV LANA and is important for virus latency" @default.
- W3215573579 cites W1487420490 @default.
- W3215573579 cites W1528147088 @default.
- W3215573579 cites W1579734686 @default.
- W3215573579 cites W1583158213 @default.
- W3215573579 cites W1975282459 @default.
- W3215573579 cites W1984289346 @default.
- W3215573579 cites W1988760901 @default.
- W3215573579 cites W1991251689 @default.
- W3215573579 cites W1991475922 @default.
- W3215573579 cites W1991952124 @default.
- W3215573579 cites W1995782808 @default.
- W3215573579 cites W2008004643 @default.
- W3215573579 cites W2008625770 @default.
- W3215573579 cites W2012346714 @default.
- W3215573579 cites W2012606436 @default.
- W3215573579 cites W2020458592 @default.
- W3215573579 cites W2025014803 @default.
- W3215573579 cites W2030400033 @default.
- W3215573579 cites W2031211461 @default.
- W3215573579 cites W2032438721 @default.
- W3215573579 cites W2037504547 @default.
- W3215573579 cites W2038926092 @default.
- W3215573579 cites W2045437181 @default.
- W3215573579 cites W2053980011 @default.
- W3215573579 cites W2054796474 @default.
- W3215573579 cites W2058268968 @default.
- W3215573579 cites W2058405696 @default.
- W3215573579 cites W2066410692 @default.
- W3215573579 cites W2066933603 @default.
- W3215573579 cites W2072194885 @default.
- W3215573579 cites W2074454759 @default.
- W3215573579 cites W2076378299 @default.
- W3215573579 cites W2076472361 @default.
- W3215573579 cites W2082281799 @default.
- W3215573579 cites W2088599859 @default.
- W3215573579 cites W2091983770 @default.
- W3215573579 cites W2093330306 @default.
- W3215573579 cites W2097493124 @default.
- W3215573579 cites W2099984271 @default.
- W3215573579 cites W2107020816 @default.
- W3215573579 cites W2108921801 @default.
- W3215573579 cites W2110599787 @default.
- W3215573579 cites W2110808180 @default.
- W3215573579 cites W2117506702 @default.
- W3215573579 cites W2118507611 @default.
- W3215573579 cites W2120478300 @default.
- W3215573579 cites W2121910267 @default.
- W3215573579 cites W2122964937 @default.
- W3215573579 cites W2124026197 @default.
- W3215573579 cites W2127976626 @default.
- W3215573579 cites W2130724559 @default.
- W3215573579 cites W2142522110 @default.
- W3215573579 cites W2146299680 @default.
- W3215573579 cites W2146501674 @default.
- W3215573579 cites W2154714625 @default.
- W3215573579 cites W2156798579 @default.
- W3215573579 cites W2158076143 @default.
- W3215573579 cites W2159211495 @default.
- W3215573579 cites W2160426448 @default.
- W3215573579 cites W2163261889 @default.
- W3215573579 cites W2163341755 @default.
- W3215573579 cites W2164433153 @default.
- W3215573579 cites W2165565773 @default.
- W3215573579 cites W2180229411 @default.
- W3215573579 cites W2277747292 @default.
- W3215573579 cites W2312580646 @default.
- W3215573579 cites W2321635162 @default.
- W3215573579 cites W2336241188 @default.
- W3215573579 cites W2402498701 @default.
- W3215573579 cites W2410723119 @default.
- W3215573579 cites W2419237034 @default.
- W3215573579 cites W2518540489 @default.
- W3215573579 cites W2581504419 @default.
- W3215573579 cites W2587240909 @default.
- W3215573579 cites W2591778276 @default.
- W3215573579 cites W2731784911 @default.
- W3215573579 cites W2790057789 @default.
- W3215573579 cites W2793311671 @default.