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- W3215577654 abstract "<b>Background and objectives:</b> Obstructive sleep apnea (OSA) patients with mild upper airway collapsibility represents a target group for potential non-positive airway pressure (PAP) treatment. We studied the clinical characteristics of this endotypic group in a large Pan-European sleep apnea registry. <b>Methods:</b> A retrospective analysis was performed in 2541 OSA patients with fixed PAP treatment (male 74%, age 53±11 years, body mass index [BMI] 33±6 kg/m<sup>2</sup>, apnea-hypopnea index [AHI] 41±25 events/h at baseline). Therapeutic PAP level ≤8 cm H<sub>2</sub>O was used as the cut-off to classify patients with mild upper airway collapsibility (Landry SA et al. Sleep 2017; 40:6). <b>Results:</b> Mean pressure of the PAP therapy was 9±2 cm H<sub>2</sub>O and treatment compliance was 5.1±2.1 h/day. A total of 39% of patients had a PAP level ≤8 cm H<sub>2</sub>O. In a multivariate logistic regression model, compared to patients with PAP >8 cm H<sub>2</sub>O, hyperlipidemia was more prevalent in mild airway collapsibility patients (OR [95%CI] 1.23 [1.00-1.51], <b>p=0.047</b>). BMI, waist-to-hip ratio, neck circumference, AHI and diagnosis of hypertension were negatively associated with the mild collapsibility group (0.97 [0.95-0.99], 0.26 [0.10-0.64], 0.96 [0.93-1.00], 0.99 [0.98-0.99], 0.75 [0.61-0.92], <b>p=0.006</b>, <b>0.003</b>, <b>0.034</b>, <b><0.001</b>, and <b>0.007</b>, respectively). PAP compliance did not differ between the mild and more severe airway collapsibility groups (p=0.89). <b>Conclusion:</b> Body composition, comorbidities and OSA severity predicted mild upper airway collapsibility defined by therapeutic PAP level in the ESADA cohort. PAP-based phenotyping approach may provide a simple tool for personalized medicine in OSA." @default.
- W3215577654 created "2021-12-06" @default.
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- W3215577654 date "2021-09-05" @default.
- W3215577654 modified "2023-09-23" @default.
- W3215577654 title "Positive airway pressure level based upper airway collapsibility classification – the European Sleep Apnea Database (ESADA)" @default.
- W3215577654 doi "https://doi.org/10.1183/13993003.congress-2021.pa2492" @default.
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