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• W3215599992 endingPage "298" @default.
• W3215599992 startingPage "285" @default.
• W3215599992 abstract "Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium produces up to three toxins, which are considered the major virulence factors in C. difficile infection. These toxins promote inflammation, tissue damage and diarrhoea. In this Review, we highlight recent biochemical and structural advances in our understanding of the mechanisms that govern host-toxin interactions. Understanding how C. difficile toxins affect the host forms a foundation for developing novel strategies for treatment and prevention of C. difficile infection." @default.
• W3215599992 created "2021-12-06" @default.
• W3215599992 creator A5014191646 @default.
• W3215599992 creator A5021582319 @default.
• W3215599992 creator A5075062584 @default.
• W3215599992 date "2021-11-26" @default.
• W3215599992 modified "2023-10-11" @default.
• W3215599992 title "Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics" @default.
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