Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215649685> ?p ?o ?g. }
- W3215649685 endingPage "5811" @default.
- W3215649685 startingPage "5811" @default.
- W3215649685 abstract "Deregulation of signaling pathways due to mutations sets the cell on a path to neoplasia. Therefore, recent reports of increased mutations observed in esophageal tissue reflects the enhanced risk of tumor formation. In fact, adenocarcinoma of the esophagus has been on the rise lately. Increase in mortality due to a paucity of efficacious drugs for this cancer prompted us to discover molecular signatures to combat this malady. To this end, we chose resveratrol-a polyphenol with anticancer property-and studied its impact on three esophageal adenocarcinoma cell lines (OE33, OE19 and FLO-1) by multilevel profiling. Here, we show the impact of resveratrol on the viability of the three adenocarcinoma esophageal cell systems studied, at the cellular level. Furthermore, an analysis at the molecular level revealed that the action was through the programmed cell death pathway, resulting in an increase in apoptotic and caspase-positive cells. The impact on reactive oxygen species (ROS) and a decrease in Bcl2 levels were also observed. Moreover, proteomic profiling highlighted pivotal differentially regulated signaling molecules. The phenotypic effect observed in resveratrol-treated esophageal cells could be due to the stoichiometry per se of the fold changes observed in entities of key signaling pathways. Notably, the downregulation of Ku80 and other pivotal entities by resveratrol could be harnessed for chemo-radiation therapy to prevent DNA break repair after radiation therapy. Additionally, multilevel profiling has shed light on molecular and immune-modulatory signatures with implications for discovering novel treatments, including chemo-immunotherapy, for esophageal adenocarcinomas which are known to be aggressive cancers." @default.
- W3215649685 created "2021-12-06" @default.
- W3215649685 creator A5025632281 @default.
- W3215649685 creator A5026466850 @default.
- W3215649685 creator A5033106046 @default.
- W3215649685 creator A5033369558 @default.
- W3215649685 creator A5045474741 @default.
- W3215649685 creator A5072608448 @default.
- W3215649685 creator A5073377479 @default.
- W3215649685 creator A5077439794 @default.
- W3215649685 creator A5082773380 @default.
- W3215649685 creator A5082819484 @default.
- W3215649685 date "2021-11-19" @default.
- W3215649685 modified "2023-10-06" @default.
- W3215649685 title "Interception of Signaling Circuits of Esophageal Adenocarcinoma Cells by Resveratrol Reveals Molecular and Immunomodulatory Signatures" @default.
- W3215649685 cites W1965645255 @default.
- W3215649685 cites W1966408852 @default.
- W3215649685 cites W1969192406 @default.
- W3215649685 cites W1976582108 @default.
- W3215649685 cites W1983863419 @default.
- W3215649685 cites W1997353566 @default.
- W3215649685 cites W2000785423 @default.
- W3215649685 cites W2001808314 @default.
- W3215649685 cites W2001865619 @default.
- W3215649685 cites W2012638373 @default.
- W3215649685 cites W2014476767 @default.
- W3215649685 cites W2017352677 @default.
- W3215649685 cites W2017726167 @default.
- W3215649685 cites W2033479986 @default.
- W3215649685 cites W2045751930 @default.
- W3215649685 cites W2046851093 @default.
- W3215649685 cites W2060420406 @default.
- W3215649685 cites W2061407456 @default.
- W3215649685 cites W2065636587 @default.
- W3215649685 cites W2068282155 @default.
- W3215649685 cites W2068819405 @default.
- W3215649685 cites W2080986274 @default.
- W3215649685 cites W2087788326 @default.
- W3215649685 cites W2087908615 @default.
- W3215649685 cites W2088542645 @default.
- W3215649685 cites W2092571669 @default.
- W3215649685 cites W2105268795 @default.
- W3215649685 cites W2110216107 @default.
- W3215649685 cites W2111274588 @default.
- W3215649685 cites W2126258731 @default.
- W3215649685 cites W2127524719 @default.
- W3215649685 cites W2143265289 @default.
- W3215649685 cites W2149726552 @default.
- W3215649685 cites W2160720859 @default.
- W3215649685 cites W2220203991 @default.
- W3215649685 cites W2238482957 @default.
- W3215649685 cites W2268205112 @default.
- W3215649685 cites W2323395911 @default.
- W3215649685 cites W2507956776 @default.
- W3215649685 cites W2513370134 @default.
- W3215649685 cites W2537976937 @default.
- W3215649685 cites W2626004372 @default.
- W3215649685 cites W2626911614 @default.
- W3215649685 cites W2766724456 @default.
- W3215649685 cites W2781813834 @default.
- W3215649685 cites W2792242317 @default.
- W3215649685 cites W2792317847 @default.
- W3215649685 cites W2800643836 @default.
- W3215649685 cites W2807608480 @default.
- W3215649685 cites W2897064819 @default.
- W3215649685 cites W2898182164 @default.
- W3215649685 cites W2913377986 @default.
- W3215649685 cites W2913493748 @default.
- W3215649685 cites W2914095913 @default.
- W3215649685 cites W2946728338 @default.
- W3215649685 cites W2947557747 @default.
- W3215649685 cites W2960168381 @default.
- W3215649685 cites W2987266888 @default.
- W3215649685 cites W2987745547 @default.
- W3215649685 cites W2990142527 @default.
- W3215649685 cites W3112281051 @default.
- W3215649685 cites W3126731632 @default.
- W3215649685 cites W3154017310 @default.
- W3215649685 doi "https://doi.org/10.3390/cancers13225811" @default.
- W3215649685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8616317" @default.
- W3215649685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34830970" @default.
- W3215649685 hasPublicationYear "2021" @default.
- W3215649685 type Work @default.
- W3215649685 sameAs 3215649685 @default.
- W3215649685 citedByCount "7" @default.
- W3215649685 countsByYear W32156496852022 @default.
- W3215649685 countsByYear W32156496852023 @default.
- W3215649685 crossrefType "journal-article" @default.
- W3215649685 hasAuthorship W3215649685A5025632281 @default.
- W3215649685 hasAuthorship W3215649685A5026466850 @default.
- W3215649685 hasAuthorship W3215649685A5033106046 @default.
- W3215649685 hasAuthorship W3215649685A5033369558 @default.
- W3215649685 hasAuthorship W3215649685A5045474741 @default.
- W3215649685 hasAuthorship W3215649685A5072608448 @default.
- W3215649685 hasAuthorship W3215649685A5073377479 @default.
- W3215649685 hasAuthorship W3215649685A5077439794 @default.
- W3215649685 hasAuthorship W3215649685A5082773380 @default.
- W3215649685 hasAuthorship W3215649685A5082819484 @default.