FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215656078> ?p ?o ?g. }

• W3215656078 endingPage "12601" @default.
• W3215656078 startingPage "12601" @default.
• W3215656078 abstract "Fungi are exposed to various environmental variables during their life cycle, including changes in CO2 concentration. CO2 has the potential to act as an activator of several cell signaling pathways. In fungi, the sensing of CO2 triggers cell differentiation and the biosynthesis of proteins involved in the metabolism and pathogenicity of these microorganisms. The molecular machineries involved in CO2 sensing constitute a promising target for the development of antifungals. Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial enzymes in the CO2 sensing systems of fungi, because they catalyze the reversible hydration of CO2 to proton and HCO3-. Bicarbonate in turn boots a cascade of reactions triggering fungal pathogenicity and metabolism. Accordingly, CAs affect microorganism proliferation and may represent a potential therapeutic target against fungal infection. Here, the inhibition of the unique β-CA (MpaCA) encoded in the genome of Malassezia pachydermatis, a fungus with substantial relevance in veterinary and medical sciences, was investigated using a series of conventional CA inhibitors (CAIs), namely aromatic and heterocyclic sulfonamides. This study aimed to describe novel candidates that can kill this harmful fungus by inhibiting their CA, and thus lead to effective anti-dandruff and anti-seborrheic dermatitis agents. In this context, current antifungal compounds, such as the azoles and their derivatives, have been demonstrated to induce the selection of resistant fungal strains and lose therapeutic efficacy, which might be restored by the concomitant use of alternative compounds, such as the fungal CA inhibitors." @default.
• W3215656078 created "2021-12-06" @default.
• W3215656078 creator A5016753502 @default.
• W3215656078 creator A5023738095 @default.
• W3215656078 creator A5036969494 @default.
• W3215656078 creator A5047307683 @default.
• W3215656078 creator A5049041759 @default.
• W3215656078 creator A5067641046 @default.
• W3215656078 creator A5067803445 @default.
• W3215656078 creator A5072935995 @default.
• W3215656078 creator A5078680549 @default.
• W3215656078 date "2021-11-22" @default.
• W3215656078 modified "2023-10-18" @default.
• W3215656078 title "Inhibitory Effects of Sulfonamide Derivatives on the β-Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis, a Commensal, Pathogenic Fungus Present in Domestic Animals" @default.
• W3215656078 cites W1573899446 @default.
• W3215656078 cites W1799884811 @default.
• W3215656078 cites W1860492593 @default.
• W3215656078 cites W1953487921 @default.
• W3215656078 cites W1975617117 @default.
• W3215656078 cites W1986711229 @default.
• W3215656078 cites W1987985725 @default.
• W3215656078 cites W1998555394 @default.
• W3215656078 cites W2014192533 @default.
• W3215656078 cites W2022295226 @default.
• W3215656078 cites W2026838488 @default.
• W3215656078 cites W2029109058 @default.
• W3215656078 cites W2029165773 @default.
• W3215656078 cites W2053542660 @default.
• W3215656078 cites W2072390676 @default.
• W3215656078 cites W2089182854 @default.
• W3215656078 cites W2096038565 @default.
• W3215656078 cites W2100837269 @default.
• W3215656078 cites W2127458359 @default.
• W3215656078 cites W2145923257 @default.
• W3215656078 cites W2235046188 @default.
• W3215656078 cites W2319251167 @default.
• W3215656078 cites W2338099075 @default.
• W3215656078 cites W2423935744 @default.
• W3215656078 cites W2433004411 @default.
• W3215656078 cites W2508831178 @default.
• W3215656078 cites W2566628151 @default.
• W3215656078 cites W2595451506 @default.
• W3215656078 cites W2606443371 @default.
• W3215656078 cites W2740506626 @default.
• W3215656078 cites W2767759051 @default.
• W3215656078 cites W2788970265 @default.
• W3215656078 cites W2792495385 @default.
• W3215656078 cites W2910584002 @default.
• W3215656078 cites W2946008902 @default.
• W3215656078 cites W2972855154 @default.
• W3215656078 cites W2998834460 @default.
• W3215656078 cites W3007881797 @default.
• W3215656078 cites W3037766364 @default.
• W3215656078 cites W3079552435 @default.
• W3215656078 cites W3111292866 @default.
• W3215656078 cites W3126696523 @default.
• W3215656078 cites W3131195470 @default.
• W3215656078 cites W3133227992 @default.
• W3215656078 cites W3154547548 @default.
• W3215656078 cites W3163437223 @default.
• W3215656078 cites W3194061326 @default.
• W3215656078 cites W4242972080 @default.
• W3215656078 cites W4293247451 @default.
• W3215656078 doi "https://doi.org/10.3390/ijms222212601" @default.
• W3215656078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8620791" @default.
• W3215656078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34830480" @default.
• W3215656078 hasPublicationYear "2021" @default.
• W3215656078 type Work @default.
• W3215656078 sameAs 3215656078 @default.
• W3215656078 citedByCount "3" @default.
• W3215656078 countsByYear W32156560782022 @default.
• W3215656078 countsByYear W32156560782023 @default.
• W3215656078 crossrefType "journal-article" @default.
• W3215656078 hasAuthorship W3215656078A5016753502 @default.
• W3215656078 hasAuthorship W3215656078A5023738095 @default.
• W3215656078 hasAuthorship W3215656078A5036969494 @default.
• W3215656078 hasAuthorship W3215656078A5047307683 @default.
• W3215656078 hasAuthorship W3215656078A5049041759 @default.
• W3215656078 hasAuthorship W3215656078A5067641046 @default.
• W3215656078 hasAuthorship W3215656078A5067803445 @default.
• W3215656078 hasAuthorship W3215656078A5072935995 @default.
• W3215656078 hasAuthorship W3215656078A5078680549 @default.
• W3215656078 hasBestOaLocation W32156560781 @default.
• W3215656078 hasConcept C151730666 @default.
• W3215656078 hasConcept C181199279 @default.
• W3215656078 hasConcept C18903297 @default.
• W3215656078 hasConcept C196405362 @default.
• W3215656078 hasConcept C2775914622 @default.
• W3215656078 hasConcept C2777472678 @default.
• W3215656078 hasConcept C2779343474 @default.
• W3215656078 hasConcept C2779678110 @default.
• W3215656078 hasConcept C55493867 @default.
• W3215656078 hasConcept C59822182 @default.
• W3215656078 hasConcept C86803240 @default.
• W3215656078 hasConcept C89423630 @default.
• W3215656078 hasConceptScore W3215656078C151730666 @default.
• W3215656078 hasConceptScore W3215656078C181199279 @default.
• W3215656078 hasConceptScore W3215656078C18903297 @default.

• next