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- W3215658413 abstract "Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the impairment of redox homeostasis and cellular death. Iron overload is often associated with haematological diseases which require regular blood transfusion/phlebotomy, and it represents a common complication in thalassaemic patients. Major damages predominantly occur in the liver and the heart, leading to a specific form of cell death recently named ferroptosis. Different from apoptosis, necrosis, and autophagy, ferroptosis is strictly dependent on iron and reactive oxygen species, with a dysregulation of mitochondrial structure/function. Susceptibility to ferroptosis is dependent on intracellular antioxidant capacity and varies according to the different cell types. Chemotherapy-induced cardiotoxicity has been proven to be mediated predominantly by iron accumulation and ferroptosis, whereas there is evidence about the role of ferritin in protecting cardiomyocytes from ferroptosis and consequent heart failure. Another paradigmatic organ for transfusion-associated complication due to iron overload is the liver, in which the role of ferroptosis is yet to be elucidated. Some studies report a role of ferroptosis in the initiation of hepatic inflammation processes while others provide evidence about an involvement in several pathologies including immune-related hepatitis and acute liver failure. In this manuscript, we aim to review the literature to address putative common features between the response to ferroptosis in the heart and liver. A better comprehension of (dys)similarities is pivotal for the development of future therapeutic strategies that can be designed to specifically target this type of cell death in an attempt to minimize iron-overload effects in specific organs." @default.
- W3215658413 created "2021-12-06" @default.
- W3215658413 creator A5006851133 @default.
- W3215658413 creator A5010445895 @default.
- W3215658413 creator A5057626276 @default.
- W3215658413 creator A5063790465 @default.
- W3215658413 creator A5080487904 @default.
- W3215658413 date "2021-11-24" @default.
- W3215658413 modified "2023-10-18" @default.
- W3215658413 title "Iron Overload, Oxidative Stress, and Ferroptosis in the Failing Heart and Liver" @default.
- W3215658413 cites W1484379620 @default.
- W3215658413 cites W1485777955 @default.
- W3215658413 cites W1565477061 @default.
- W3215658413 cites W1568912715 @default.
- W3215658413 cites W1910071664 @default.
- W3215658413 cites W1969515779 @default.
- W3215658413 cites W1972998779 @default.
- W3215658413 cites W1973152120 @default.
- W3215658413 cites W1977664045 @default.
- W3215658413 cites W1977731938 @default.
- W3215658413 cites W1983799237 @default.
- W3215658413 cites W1986119180 @default.
- W3215658413 cites W1991039871 @default.
- W3215658413 cites W1991627669 @default.
- W3215658413 cites W1996152690 @default.
- W3215658413 cites W1997183854 @default.
- W3215658413 cites W1998872310 @default.
- W3215658413 cites W1999236279 @default.
- W3215658413 cites W2000087607 @default.
- W3215658413 cites W2000379537 @default.
- W3215658413 cites W2006408919 @default.
- W3215658413 cites W2007794772 @default.
- W3215658413 cites W2012486557 @default.
- W3215658413 cites W2017498511 @default.
- W3215658413 cites W2018411741 @default.
- W3215658413 cites W2020369221 @default.
- W3215658413 cites W2023024417 @default.
- W3215658413 cites W2029915182 @default.
- W3215658413 cites W2030713637 @default.
- W3215658413 cites W2035898183 @default.
- W3215658413 cites W2045143928 @default.
- W3215658413 cites W2045171661 @default.
- W3215658413 cites W2047498064 @default.
- W3215658413 cites W2058581405 @default.
- W3215658413 cites W2063456851 @default.
- W3215658413 cites W2063663321 @default.
- W3215658413 cites W2064233448 @default.
- W3215658413 cites W2072829138 @default.
- W3215658413 cites W2080206372 @default.
- W3215658413 cites W2082115021 @default.
- W3215658413 cites W2083867296 @default.
- W3215658413 cites W2086567353 @default.
- W3215658413 cites W2087584242 @default.
- W3215658413 cites W2089779289 @default.
- W3215658413 cites W2094190961 @default.
- W3215658413 cites W2095075233 @default.
- W3215658413 cites W2097014671 @default.
- W3215658413 cites W2100671540 @default.
- W3215658413 cites W2101222093 @default.
- W3215658413 cites W2103416581 @default.
- W3215658413 cites W2106447915 @default.
- W3215658413 cites W2107704801 @default.
- W3215658413 cites W2108489423 @default.
- W3215658413 cites W2110678838 @default.
- W3215658413 cites W2111148351 @default.
- W3215658413 cites W2111630376 @default.
- W3215658413 cites W2114190171 @default.
- W3215658413 cites W2115063167 @default.
- W3215658413 cites W2115953418 @default.
- W3215658413 cites W2119221698 @default.
- W3215658413 cites W2119851117 @default.
- W3215658413 cites W2120579517 @default.
- W3215658413 cites W2124709834 @default.
- W3215658413 cites W2142157062 @default.
- W3215658413 cites W2146771910 @default.
- W3215658413 cites W2154254146 @default.
- W3215658413 cites W2157602735 @default.
- W3215658413 cites W2158155007 @default.
- W3215658413 cites W2163005196 @default.
- W3215658413 cites W2163294546 @default.
- W3215658413 cites W2170385041 @default.
- W3215658413 cites W2170885365 @default.
- W3215658413 cites W2172487604 @default.
- W3215658413 cites W2234023838 @default.
- W3215658413 cites W2305753128 @default.
- W3215658413 cites W2330845108 @default.
- W3215658413 cites W2346697308 @default.
- W3215658413 cites W2358356329 @default.
- W3215658413 cites W2399192198 @default.
- W3215658413 cites W2414659015 @default.
- W3215658413 cites W2499821194 @default.
- W3215658413 cites W2518357275 @default.
- W3215658413 cites W2549188196 @default.
- W3215658413 cites W2559410759 @default.
- W3215658413 cites W2559736529 @default.
- W3215658413 cites W2587925611 @default.
- W3215658413 cites W2605241944 @default.
- W3215658413 cites W2614710189 @default.