FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215663838> ?p ?o ?g. }

• W3215663838 endingPage "106689" @default.
• W3215663838 startingPage "106689" @default.
• W3215663838 abstract "The clinical course of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable. The Krebs von den Lungen-6 (KL-6) glycoprotein is a promising biomarker for reflecting epithelial injury. However, serum KL-6 and its association with the progression of SSc-ILD have been understudied.We reviewed 77 consecutive patients with SSc-ILD seen from 2004 to 2016. A longitudinal study of forced vital capacity (FVC), serum KL-6 levels, and changes in KL-6 levels from baseline (ΔKL-6) was conducted. The progression of ILD was defined as ≥10% relative decline in FVC predicted or 5%-10% decline in FVC predicted along with radiological progression on chest computed tomography. The risk factors for ILD progression were assessed by univariate and multivariate regression.During a 5-year follow-up period, 10 (13%) patients showed rapid progression of ILD within 2 years, 39 (51%) showed overall progression during the 5 years, and 28 (36%) had stable disease. Most patients with progressive ILD showed elevations in serum KL-6 levels over the initial 1-year follow-up period. The best cut-off value for ΔKL-6 that predicted progression of ILD was 193 U/mL (sensitivity 81.6%, specificity 92.9%). Multivariate analysis adjusted by age, sex, smoking status, and immunosuppressant use found that diffuse cutaneous SSc (hazard ratio [HR] 4.51; 95% confidence interval [CI] 1.56-13.04) and ΔKL-6 > 193 U/mL from baseline (HR 7.19; 95% CI 3.30-15.69) were independent predictors for progression of SSc-ILD.Changes in the KL-6 level can be useful for predicting disease progression in patients with SSc-ILD." @default.
• W3215663838 created "2021-12-06" @default.
• W3215663838 creator A5002945177 @default.
• W3215663838 creator A5006748318 @default.
• W3215663838 creator A5012144941 @default.
• W3215663838 creator A5012788363 @default.
• W3215663838 creator A5018690593 @default.
• W3215663838 creator A5023225309 @default.
• W3215663838 creator A5025298732 @default.
• W3215663838 creator A5026861577 @default.
• W3215663838 creator A5065666401 @default.
• W3215663838 creator A5082793646 @default.
• W3215663838 date "2022-01-01" @default.
• W3215663838 modified "2023-10-17" @default.
• W3215663838 title "Kinetic changes in serum KL-6 levels predict disease progression in patients with systemic sclerosis-associated interstitial lung disease" @default.
• W3215663838 cites W2047974491 @default.
• W3215663838 cites W2071779792 @default.
• W3215663838 cites W2108581097 @default.
• W3215663838 cites W2116531828 @default.
• W3215663838 cites W2118749321 @default.
• W3215663838 cites W2131014787 @default.
• W3215663838 cites W2143997148 @default.
• W3215663838 cites W2147543851 @default.
• W3215663838 cites W2416914730 @default.
• W3215663838 cites W2504680161 @default.
• W3215663838 cites W2508060872 @default.
• W3215663838 cites W2605548119 @default.
• W3215663838 cites W2751901150 @default.
• W3215663838 cites W2782208928 @default.
• W3215663838 cites W2807354082 @default.
• W3215663838 cites W2889197569 @default.
• W3215663838 cites W2890199186 @default.
• W3215663838 cites W2900158663 @default.
• W3215663838 cites W2945521814 @default.
• W3215663838 cites W2995067265 @default.
• W3215663838 cites W3007003780 @default.
• W3215663838 cites W3081624185 @default.
• W3215663838 cites W3089161952 @default.
• W3215663838 cites W3173594498 @default.
• W3215663838 doi "https://doi.org/10.1016/j.rmed.2021.106689" @default.
• W3215663838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34844174" @default.
• W3215663838 hasPublicationYear "2022" @default.
• W3215663838 type Work @default.
• W3215663838 sameAs 3215663838 @default.
• W3215663838 citedByCount "2" @default.
• W3215663838 countsByYear W32156638382023 @default.
• W3215663838 crossrefType "journal-article" @default.
• W3215663838 hasAuthorship W3215663838A5002945177 @default.
• W3215663838 hasAuthorship W3215663838A5006748318 @default.
• W3215663838 hasAuthorship W3215663838A5012144941 @default.
• W3215663838 hasAuthorship W3215663838A5012788363 @default.
• W3215663838 hasAuthorship W3215663838A5018690593 @default.
• W3215663838 hasAuthorship W3215663838A5023225309 @default.
• W3215663838 hasAuthorship W3215663838A5025298732 @default.
• W3215663838 hasAuthorship W3215663838A5026861577 @default.
• W3215663838 hasAuthorship W3215663838A5065666401 @default.
• W3215663838 hasAuthorship W3215663838A5082793646 @default.
• W3215663838 hasBestOaLocation W32156638381 @default.
• W3215663838 hasConcept C126322002 @default.
• W3215663838 hasConcept C144301174 @default.
• W3215663838 hasConcept C165637977 @default.
• W3215663838 hasConcept C185592680 @default.
• W3215663838 hasConcept C207103383 @default.
• W3215663838 hasConcept C2777543607 @default.
• W3215663838 hasConcept C2777714996 @default.
• W3215663838 hasConcept C2781197716 @default.
• W3215663838 hasConcept C3018587741 @default.
• W3215663838 hasConcept C38180746 @default.
• W3215663838 hasConcept C44249647 @default.
• W3215663838 hasConcept C50382708 @default.
• W3215663838 hasConcept C55493867 @default.
• W3215663838 hasConcept C55520419 @default.
• W3215663838 hasConcept C71924100 @default.
• W3215663838 hasConcept C90924648 @default.
• W3215663838 hasConceptScore W3215663838C126322002 @default.
• W3215663838 hasConceptScore W3215663838C144301174 @default.
• W3215663838 hasConceptScore W3215663838C165637977 @default.
• W3215663838 hasConceptScore W3215663838C185592680 @default.
• W3215663838 hasConceptScore W3215663838C207103383 @default.
• W3215663838 hasConceptScore W3215663838C2777543607 @default.
• W3215663838 hasConceptScore W3215663838C2777714996 @default.
• W3215663838 hasConceptScore W3215663838C2781197716 @default.
• W3215663838 hasConceptScore W3215663838C3018587741 @default.
• W3215663838 hasConceptScore W3215663838C38180746 @default.
• W3215663838 hasConceptScore W3215663838C44249647 @default.
• W3215663838 hasConceptScore W3215663838C50382708 @default.
• W3215663838 hasConceptScore W3215663838C55493867 @default.
• W3215663838 hasConceptScore W3215663838C55520419 @default.
• W3215663838 hasConceptScore W3215663838C71924100 @default.
• W3215663838 hasConceptScore W3215663838C90924648 @default.
• W3215663838 hasLocation W32156638381 @default.
• W3215663838 hasLocation W32156638382 @default.
• W3215663838 hasOpenAccess W3215663838 @default.
• W3215663838 hasPrimaryLocation W32156638381 @default.
• W3215663838 hasRelatedWork W1727188710 @default.
• W3215663838 hasRelatedWork W2088206352 @default.
• W3215663838 hasRelatedWork W2119154902 @default.
• W3215663838 hasRelatedWork W2119410072 @default.

• next