FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215668516> ?p ?o ?g. }

• W3215668516 endingPage "778" @default.
• W3215668516 startingPage "768" @default.
• W3215668516 abstract "Pegvaliase is approved to reduce phenylalanine (Phe) levels for people with phenylketonuria (PKU). PRISM-1 (NCT01819727) and PRISM-2 (NCT01889862) data were analyzed to evaluate the relationship between Phe and inattention in adult participants with PKU. In the modified-intent-to-treat population (N = 156), baseline mean (SE) plasma Phe was 1263 (29) μmol/L and the Attention Deficit Hyperactivity Disorder Rating Scale-IV Inattentive (IA) symptoms score was 9.8 (0.5). Mean (SE) IA scores fell 9.0 (1.1) in Quartile 1 (Phe reduction between 1166 and 2229 μmol/L) versus 4.3 (0.7) in Quartile 4 (Phe reduction of 139 μmol/L to increase of 934 μmol/L), p = 0.004. Least squares mean (SE) change from baseline IA score was −7.9 (0.7) for participants with final Phe ≤ 360 μmol/L and −4.5 (0.7) for final Phe > 360 μmol/L, p < 0.001. In the inattention subgroup, IA scores fell 13.3 (1.5) in Quartile 1 (Phe reduction between 1288 and 2229 μmol/L) versus 6.2 (1.3) in Quartile 4 (Phe reduction of 247 to increase of 934 μmol/L), p = 0.009. Inattention symptoms improved among those whose Phe levels decreased, particularly those with high baseline IA scores. IA improvements were larger among participants with the greatest plasma Phe reductions, supporting this value as a therapeutic goal." @default.
• W3215668516 created "2021-12-06" @default.
• W3215668516 creator A5012665822 @default.
• W3215668516 creator A5015936523 @default.
• W3215668516 creator A5032217427 @default.
• W3215668516 creator A5034176312 @default.
• W3215668516 creator A5048616691 @default.
• W3215668516 creator A5049047009 @default.
• W3215668516 creator A5053985689 @default.
• W3215668516 creator A5057858235 @default.
• W3215668516 creator A5064200493 @default.
• W3215668516 creator A5065559493 @default.
• W3215668516 creator A5071661161 @default.
• W3215668516 date "2021-11-26" @default.
• W3215668516 modified "2023-10-16" @default.
• W3215668516 title "Improved attention linked to sustained phenylalanine reduction in adults with early‐treated phenylketonuria" @default.
• W3215668516 cites W148038377 @default.
• W3215668516 cites W167318638 @default.
• W3215668516 cites W1967701933 @default.
• W3215668516 cites W1971746851 @default.
• W3215668516 cites W1977343599 @default.
• W3215668516 cites W1977671837 @default.
• W3215668516 cites W1979206088 @default.
• W3215668516 cites W1984982865 @default.
• W3215668516 cites W1990591430 @default.
• W3215668516 cites W1992214296 @default.
• W3215668516 cites W2001072757 @default.
• W3215668516 cites W2002176425 @default.
• W3215668516 cites W2006682072 @default.
• W3215668516 cites W2026161891 @default.
• W3215668516 cites W2035927721 @default.
• W3215668516 cites W2042661061 @default.
• W3215668516 cites W2045169592 @default.
• W3215668516 cites W2054755825 @default.
• W3215668516 cites W2070682452 @default.
• W3215668516 cites W2072184486 @default.
• W3215668516 cites W2091962570 @default.
• W3215668516 cites W2094205543 @default.
• W3215668516 cites W2203990144 @default.
• W3215668516 cites W2547207239 @default.
• W3215668516 cites W2572123485 @default.
• W3215668516 cites W2591640554 @default.
• W3215668516 cites W2761810763 @default.
• W3215668516 cites W2793449864 @default.
• W3215668516 cites W2795291721 @default.
• W3215668516 cites W2957007442 @default.
• W3215668516 cites W3093958232 @default.
• W3215668516 cites W3122450085 @default.
• W3215668516 cites W3174804778 @default.
• W3215668516 cites W3215668516 @default.
• W3215668516 cites W4211112701 @default.
• W3215668516 cites W4247665917 @default.
• W3215668516 doi "https://doi.org/10.1002/ajmg.a.62574" @default.
• W3215668516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34826353" @default.
• W3215668516 hasPublicationYear "2021" @default.
• W3215668516 type Work @default.
• W3215668516 sameAs 3215668516 @default.
• W3215668516 citedByCount "9" @default.
• W3215668516 countsByYear W32156685162021 @default.
• W3215668516 countsByYear W32156685162022 @default.
• W3215668516 countsByYear W32156685162023 @default.
• W3215668516 crossrefType "journal-article" @default.
• W3215668516 hasAuthorship W3215668516A5012665822 @default.
• W3215668516 hasAuthorship W3215668516A5015936523 @default.
• W3215668516 hasAuthorship W3215668516A5032217427 @default.
• W3215668516 hasAuthorship W3215668516A5034176312 @default.
• W3215668516 hasAuthorship W3215668516A5048616691 @default.
• W3215668516 hasAuthorship W3215668516A5049047009 @default.
• W3215668516 hasAuthorship W3215668516A5053985689 @default.
• W3215668516 hasAuthorship W3215668516A5057858235 @default.
• W3215668516 hasAuthorship W3215668516A5064200493 @default.
• W3215668516 hasAuthorship W3215668516A5065559493 @default.
• W3215668516 hasAuthorship W3215668516A5071661161 @default.
• W3215668516 hasBestOaLocation W32156685162 @default.
• W3215668516 hasConcept C126322002 @default.
• W3215668516 hasConcept C134018914 @default.
• W3215668516 hasConcept C185592680 @default.
• W3215668516 hasConcept C2777431362 @default.
• W3215668516 hasConcept C2908647359 @default.
• W3215668516 hasConcept C2908963387 @default.
• W3215668516 hasConcept C44249647 @default.
• W3215668516 hasConcept C515207424 @default.
• W3215668516 hasConcept C55493867 @default.
• W3215668516 hasConcept C68443243 @default.
• W3215668516 hasConcept C71924100 @default.
• W3215668516 hasConcept C99454951 @default.
• W3215668516 hasConceptScore W3215668516C126322002 @default.
• W3215668516 hasConceptScore W3215668516C134018914 @default.
• W3215668516 hasConceptScore W3215668516C185592680 @default.
• W3215668516 hasConceptScore W3215668516C2777431362 @default.
• W3215668516 hasConceptScore W3215668516C2908647359 @default.
• W3215668516 hasConceptScore W3215668516C2908963387 @default.
• W3215668516 hasConceptScore W3215668516C44249647 @default.
• W3215668516 hasConceptScore W3215668516C515207424 @default.
• W3215668516 hasConceptScore W3215668516C55493867 @default.
• W3215668516 hasConceptScore W3215668516C68443243 @default.
• W3215668516 hasConceptScore W3215668516C71924100 @default.
• W3215668516 hasConceptScore W3215668516C99454951 @default.

• next