Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215669069> ?p ?o ?g. }
- W3215669069 abstract "ABSTRACT Melanopsin is a visual pigment that is expressed in a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs). It is involved in regulating non-image forming visual behaviors, such as circadian photoentrainment and the pupillary light reflex, while also playing a role in many aspects of image-forming vision, such as contrast sensitivity. Melanopsin was initially discovered in the melanophores of the skin of the frog Xenopus, and subsequently found in a subset of ganglion cells in rat, mouse and primate retinas. ipRGCs were initially thought to be a single retinal ganglion cell population, and melanopsin was thought to activate a single, invertebrate-like Gq/transient receptor potential canonical (TRPC)-based phototransduction cascade within these cells. However, in the 20 years since the discovery of melanopsin, our knowledge of this visual pigment and ipRGCs has expanded dramatically. Six ipRGC subtypes have now been identified in the mouse, each with unique morphological, physiological and functional properties. Multiple subtypes have also been identified in other species, suggesting that this cell type diversity is a general feature of the ipRGC system. This diversity has led to a renewed interest in melanopsin phototransduction that may not follow the canonical Gq/TRPC cascade in the mouse or in the plethora of other organisms that express the melanopsin photopigment. In this Review, we discuss recent findings and discoveries that have challenged the prevailing view of melanopsin phototransduction as a single pathway that influences solely non-image forming functions." @default.
- W3215669069 created "2021-12-06" @default.
- W3215669069 creator A5005525744 @default.
- W3215669069 creator A5018265341 @default.
- W3215669069 creator A5050622273 @default.
- W3215669069 creator A5087482215 @default.
- W3215669069 date "2021-11-29" @default.
- W3215669069 modified "2023-10-17" @default.
- W3215669069 title "Melanopsin phototransduction: beyond canonical cascades" @default.
- W3215669069 cites W1488048016 @default.
- W3215669069 cites W1560950175 @default.
- W3215669069 cites W1591959848 @default.
- W3215669069 cites W1862406226 @default.
- W3215669069 cites W1895211345 @default.
- W3215669069 cites W1915011327 @default.
- W3215669069 cites W1963597898 @default.
- W3215669069 cites W1967473768 @default.
- W3215669069 cites W1967495778 @default.
- W3215669069 cites W1971238746 @default.
- W3215669069 cites W1971524741 @default.
- W3215669069 cites W1974216069 @default.
- W3215669069 cites W1976525115 @default.
- W3215669069 cites W1977388717 @default.
- W3215669069 cites W1979530387 @default.
- W3215669069 cites W1981503145 @default.
- W3215669069 cites W1983875092 @default.
- W3215669069 cites W1984116068 @default.
- W3215669069 cites W1985349513 @default.
- W3215669069 cites W1985806794 @default.
- W3215669069 cites W1986209073 @default.
- W3215669069 cites W1986522060 @default.
- W3215669069 cites W1989665437 @default.
- W3215669069 cites W1992420220 @default.
- W3215669069 cites W1992790774 @default.
- W3215669069 cites W1993244384 @default.
- W3215669069 cites W1995481744 @default.
- W3215669069 cites W1997857485 @default.
- W3215669069 cites W2002081009 @default.
- W3215669069 cites W2006130774 @default.
- W3215669069 cites W2006712537 @default.
- W3215669069 cites W2009077913 @default.
- W3215669069 cites W2011845346 @default.
- W3215669069 cites W2011964190 @default.
- W3215669069 cites W2013579519 @default.
- W3215669069 cites W2014028088 @default.
- W3215669069 cites W2019233831 @default.
- W3215669069 cites W2019742616 @default.
- W3215669069 cites W2022197238 @default.
- W3215669069 cites W2023126912 @default.
- W3215669069 cites W2029307250 @default.
- W3215669069 cites W2030065502 @default.
- W3215669069 cites W2030366252 @default.
- W3215669069 cites W2031626699 @default.
- W3215669069 cites W2031675933 @default.
- W3215669069 cites W2035853180 @default.
- W3215669069 cites W2036239753 @default.
- W3215669069 cites W2038854117 @default.
- W3215669069 cites W2041245092 @default.
- W3215669069 cites W2042432891 @default.
- W3215669069 cites W2043842765 @default.
- W3215669069 cites W2045714429 @default.
- W3215669069 cites W2046289352 @default.
- W3215669069 cites W2048112824 @default.
- W3215669069 cites W2054544118 @default.
- W3215669069 cites W2055800694 @default.
- W3215669069 cites W2056888759 @default.
- W3215669069 cites W2057601872 @default.
- W3215669069 cites W2061683639 @default.
- W3215669069 cites W2064069419 @default.
- W3215669069 cites W2064875912 @default.
- W3215669069 cites W2064995753 @default.
- W3215669069 cites W2067301534 @default.
- W3215669069 cites W2069342665 @default.
- W3215669069 cites W2070154168 @default.
- W3215669069 cites W2071387289 @default.
- W3215669069 cites W2073028192 @default.
- W3215669069 cites W2073148060 @default.
- W3215669069 cites W2074271273 @default.
- W3215669069 cites W2076727881 @default.
- W3215669069 cites W2077759537 @default.
- W3215669069 cites W2077962766 @default.
- W3215669069 cites W2081024860 @default.
- W3215669069 cites W2081957674 @default.
- W3215669069 cites W2084710483 @default.
- W3215669069 cites W2088428828 @default.
- W3215669069 cites W2092510003 @default.
- W3215669069 cites W2093926336 @default.
- W3215669069 cites W2097706568 @default.
- W3215669069 cites W2100268416 @default.
- W3215669069 cites W2101151402 @default.
- W3215669069 cites W2103951666 @default.
- W3215669069 cites W2105050095 @default.
- W3215669069 cites W2107083462 @default.
- W3215669069 cites W2107550000 @default.
- W3215669069 cites W2110209988 @default.
- W3215669069 cites W2110382306 @default.
- W3215669069 cites W2111530177 @default.
- W3215669069 cites W2117649297 @default.
- W3215669069 cites W2118108368 @default.
- W3215669069 cites W2118673846 @default.