Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215670011> ?p ?o ?g. }
- W3215670011 endingPage "108886" @default.
- W3215670011 startingPage "108886" @default.
- W3215670011 abstract "Metabotropic glutamate receptors (mGluRs) have been discovered almost four decades ago. Since then, their pharmacology has been largely developed as well as their structural organization. Indeed mGluRs are attractive therapeutic targets for numerous psychiatric and neurological disorders because of their modulating role of synaptic transmission. The more recent drug discovery programs have mostly concentrated on allosteric modulators. However, orthosteric agonists and antagonists have remained unavoidable pharmacological tools as, although not expected, many of them can reach the brain, or can be modified to reach the brain. This review focuses on the most common orthosteric ligands as well as on the few allosteric modulators interacting with the glutamate binding domain. The 3D-structures of these ligands at their binding sites are reported. For most of them, X-Ray structures or docked homology models are available. Because of the high conservation of the binding site, subtype selective agonists were not easy to find. Yet, some were discovered when extending their chemical structures in order to reach selective sites of the receptors." @default.
- W3215670011 created "2021-12-06" @default.
- W3215670011 creator A5003513918 @default.
- W3215670011 creator A5042650421 @default.
- W3215670011 creator A5055221792 @default.
- W3215670011 creator A5066336341 @default.
- W3215670011 creator A5068275125 @default.
- W3215670011 date "2022-02-01" @default.
- W3215670011 modified "2023-09-30" @default.
- W3215670011 title "Metabotropic glutamate receptor orthosteric ligands and their binding sites" @default.
- W3215670011 cites W1487123995 @default.
- W3215670011 cites W1608735505 @default.
- W3215670011 cites W1811771892 @default.
- W3215670011 cites W1945680072 @default.
- W3215670011 cites W1967113275 @default.
- W3215670011 cites W1980847901 @default.
- W3215670011 cites W1987749248 @default.
- W3215670011 cites W1993409548 @default.
- W3215670011 cites W1997113206 @default.
- W3215670011 cites W2005913521 @default.
- W3215670011 cites W2007051067 @default.
- W3215670011 cites W2007566102 @default.
- W3215670011 cites W2007635892 @default.
- W3215670011 cites W2011461371 @default.
- W3215670011 cites W2013432476 @default.
- W3215670011 cites W2016413308 @default.
- W3215670011 cites W2016867645 @default.
- W3215670011 cites W2023343746 @default.
- W3215670011 cites W2035267273 @default.
- W3215670011 cites W2042255217 @default.
- W3215670011 cites W2042882165 @default.
- W3215670011 cites W2043166209 @default.
- W3215670011 cites W2052935274 @default.
- W3215670011 cites W2054202278 @default.
- W3215670011 cites W2058591676 @default.
- W3215670011 cites W2066439205 @default.
- W3215670011 cites W2069841740 @default.
- W3215670011 cites W2075591794 @default.
- W3215670011 cites W2077202970 @default.
- W3215670011 cites W2079388530 @default.
- W3215670011 cites W2085210285 @default.
- W3215670011 cites W2085988072 @default.
- W3215670011 cites W2092830941 @default.
- W3215670011 cites W2093325915 @default.
- W3215670011 cites W2093440950 @default.
- W3215670011 cites W2094016025 @default.
- W3215670011 cites W2106042714 @default.
- W3215670011 cites W2112378137 @default.
- W3215670011 cites W2114324341 @default.
- W3215670011 cites W2116386279 @default.
- W3215670011 cites W2120307371 @default.
- W3215670011 cites W2128603289 @default.
- W3215670011 cites W2137376734 @default.
- W3215670011 cites W2144324767 @default.
- W3215670011 cites W2159338698 @default.
- W3215670011 cites W2162327153 @default.
- W3215670011 cites W2180941170 @default.
- W3215670011 cites W2197573573 @default.
- W3215670011 cites W2274383865 @default.
- W3215670011 cites W2556458733 @default.
- W3215670011 cites W2559719377 @default.
- W3215670011 cites W2582775862 @default.
- W3215670011 cites W2582906114 @default.
- W3215670011 cites W2725906416 @default.
- W3215670011 cites W2744794320 @default.
- W3215670011 cites W2775795535 @default.
- W3215670011 cites W2785138913 @default.
- W3215670011 cites W2786342227 @default.
- W3215670011 cites W2860912964 @default.
- W3215670011 cites W2885322774 @default.
- W3215670011 cites W2887215900 @default.
- W3215670011 cites W2898447746 @default.
- W3215670011 cites W2911446286 @default.
- W3215670011 cites W2913688424 @default.
- W3215670011 cites W2951764089 @default.
- W3215670011 cites W2993482567 @default.
- W3215670011 cites W3021368381 @default.
- W3215670011 cites W3036443046 @default.
- W3215670011 cites W3119175664 @default.
- W3215670011 cites W3167499727 @default.
- W3215670011 cites W3176996497 @default.
- W3215670011 cites W3193135438 @default.
- W3215670011 cites W4230699332 @default.
- W3215670011 doi "https://doi.org/10.1016/j.neuropharm.2021.108886" @default.
- W3215670011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34813860" @default.
- W3215670011 hasPublicationYear "2022" @default.
- W3215670011 type Work @default.
- W3215670011 sameAs 3215670011 @default.
- W3215670011 citedByCount "7" @default.
- W3215670011 countsByYear W32156700112022 @default.
- W3215670011 countsByYear W32156700112023 @default.
- W3215670011 crossrefType "journal-article" @default.
- W3215670011 hasAuthorship W3215670011A5003513918 @default.
- W3215670011 hasAuthorship W3215670011A5042650421 @default.
- W3215670011 hasAuthorship W3215670011A5055221792 @default.
- W3215670011 hasAuthorship W3215670011A5066336341 @default.
- W3215670011 hasAuthorship W3215670011A5068275125 @default.
- W3215670011 hasBestOaLocation W32156700111 @default.