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- W3215671971 abstract "Type 2 diabetes (T2D) is a worldwide prevalent metabolic disorder defined by high blood glucose levels due to insulin resistance (IR) and impaired insulin secretion. Understanding the mechanism of insulin action is of great importance to the continuing development of novel therapeutic strategies for the treatment of T2D. Disturbances of gut microbiota have been widely found in T2D patients and contribute to the development of IR. In the present article, we reviewed the pathological role of gut microbial metabolites including gaseous products, branched-chain amino acids (BCAAs) products, aromatic amino acids (AAAs) products, bile acids (BA) products, choline products and bacterial toxins in regulating insulin sensitivity in T2D. Following that, we summarized probiotics-based therapeutic strategy for the treatment of T2D with a focus on modulating gut microbiota in both animal and human studies. These results indicate that gut-microbial metabolites are involved in the pathogenesis of T2D and supplementation of probiotics could be beneficial to alleviate IR in T2D via modulation of gut microbiota." @default.
- W3215671971 created "2021-12-06" @default.
- W3215671971 creator A5005605702 @default.
- W3215671971 creator A5024614916 @default.
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- W3215671971 creator A5074425597 @default.
- W3215671971 creator A5077928620 @default.
- W3215671971 creator A5089695340 @default.
- W3215671971 date "2021-11-27" @default.
- W3215671971 modified "2023-10-17" @default.
- W3215671971 title "Gut-Microbial Metabolites, Probiotics and Their Roles in Type 2 Diabetes" @default.
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