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- W3215673818 abstract "The dissolution of poorly water-soluble drug is always an important challenge in pharmaceutics during the past half century. Solid dispersion (SD) is viewed as a useful medicated material for resolving this issue. Today, SD is going into the fifth generation, in which complicated nanostructures are explored for promoting the fast dissolution and immediate release of poorly water-soluble from the loaded matrices. In this investigation, a modified coaxial electrospinning was exploited to prepare the fifth generation SD for the fast dissolution of ibuprofen (IBU), which was in the form of core-shell nanofibers. Different types of polyvinylpyrrolidone (PVP) were explored as the shell and core matrices. For easy electrospinning, the core fluid was pure solution of PVP K90 in ethanol (8% wt.). But for fast dissolution, the shell fluid was a blending solution of PVP K10 and drug IBU (5% wt. and 10% wt., respectively). The core-shell nanofibers had an average diameter of 780 ± 120 nm with a uniform structure and smooth surface. X-ray diffraction results demonstrated that IBU was distributed homogeneously and amorphously in the PVP K10 matrix due to favorable second-order interactions. In vitro dissolution tests demonstrated that the fifth generation SDs could rapidly release IBU within one minute, over 20 times faster than the raw IBU particles. The present investigation provides an example of the systematic design, preparation, characterization, and application of the advanced fifth generation SDs consisting of different types hydrophilic polymers and poorly water-soluble drug within the complicated nanostructures." @default.
- W3215673818 created "2021-12-06" @default.
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- W3215673818 date "2021-11-22" @default.
- W3215673818 modified "2023-09-27" @default.
- W3215673818 title "Electrospun the fifth generation solid dispersion of ibuprofen based on a hydrophilic polymeric excipient" @default.
- W3215673818 doi "https://doi.org/10.1201/9781003225850-43" @default.
- W3215673818 hasPublicationYear "2021" @default.
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