Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215673928> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W3215673928 abstract "Background: Both animal and clinical studies have demonstrated that hypertension is associated with altered vasomotor tone. However, the direct effect of well-controlled and poorly (un)controlled hypertension on the myogenic tone of human coronary arterioles is inadequately investigated. Objective: We investigated the effect of well-controlled and poorly (un)controlled HTN on the myogenic tone of human coronary arterioles. Methods: Coronary arterioles pre-cardiopulmonary bypass were dissected from harvested atrial tissue samples of eligible patients. Patients were categorized as having normal blood pressure, or well-controlled or poorly-(un)controlled hypertension (n = 5-8/group). Myogenic tone in response to stepwise increases in intraluminal pressure was studied between pressure steps. The microvascular reactivity in response to the selective α-adrenergic agonist phenylephrine was also assessed via vessel myography. Results: Increased myogenic tone was reflected by a decreases in microvessel internal diameter in all patients. There was a significant increase in myogenic tone in patients with poorly (un)controlled hypertension (0.97±0.05 in diameter ) compared with normotensive patients (1.27±0.14 in diameter, P = 0.001). The contractile response to phenylephrine was significantly enhanced in patients with poorly (un)controlled hypertension compared with normotensive patients (P<0.001). However, there were no significant differences in the myogenic tone or phenylephrine-induced vasomotor tone between normotensive patients and patients with well-controlled hypertension (P>0.05 respectively). Conclusion: Poorly (un)controlled hypertension is associated with increases in coronary arteriolar myogenic and vasomotor tone, which may contribute to the increased coronary vasospasm seen in this population." @default.
- W3215673928 created "2021-12-06" @default.
- W3215673928 creator A5004326219 @default.
- W3215673928 creator A5006555075 @default.
- W3215673928 creator A5012657061 @default.
- W3215673928 creator A5022713023 @default.
- W3215673928 creator A5063617416 @default.
- W3215673928 creator A5083654638 @default.
- W3215673928 creator A5084429071 @default.
- W3215673928 creator A5091383353 @default.
- W3215673928 date "2021-11-16" @default.
- W3215673928 modified "2023-09-25" @default.
- W3215673928 title "Abstract 14055: Increased Coronary Myogenic Tone in Patients With Poorly Controlled Hypertension" @default.
- W3215673928 doi "https://doi.org/10.1161/circ.144.suppl_1.14055" @default.
- W3215673928 hasPublicationYear "2021" @default.
- W3215673928 type Work @default.
- W3215673928 sameAs 3215673928 @default.
- W3215673928 citedByCount "0" @default.
- W3215673928 crossrefType "journal-article" @default.
- W3215673928 hasAuthorship W3215673928A5004326219 @default.
- W3215673928 hasAuthorship W3215673928A5006555075 @default.
- W3215673928 hasAuthorship W3215673928A5012657061 @default.
- W3215673928 hasAuthorship W3215673928A5022713023 @default.
- W3215673928 hasAuthorship W3215673928A5063617416 @default.
- W3215673928 hasAuthorship W3215673928A5083654638 @default.
- W3215673928 hasAuthorship W3215673928A5084429071 @default.
- W3215673928 hasAuthorship W3215673928A5091383353 @default.
- W3215673928 hasConcept C120770815 @default.
- W3215673928 hasConcept C126322002 @default.
- W3215673928 hasConcept C164705383 @default.
- W3215673928 hasConcept C1918360 @default.
- W3215673928 hasConcept C2776214587 @default.
- W3215673928 hasConcept C2777952589 @default.
- W3215673928 hasConcept C2779961880 @default.
- W3215673928 hasConcept C2992686903 @default.
- W3215673928 hasConcept C58336856 @default.
- W3215673928 hasConcept C71924100 @default.
- W3215673928 hasConcept C84393581 @default.
- W3215673928 hasConceptScore W3215673928C120770815 @default.
- W3215673928 hasConceptScore W3215673928C126322002 @default.
- W3215673928 hasConceptScore W3215673928C164705383 @default.
- W3215673928 hasConceptScore W3215673928C1918360 @default.
- W3215673928 hasConceptScore W3215673928C2776214587 @default.
- W3215673928 hasConceptScore W3215673928C2777952589 @default.
- W3215673928 hasConceptScore W3215673928C2779961880 @default.
- W3215673928 hasConceptScore W3215673928C2992686903 @default.
- W3215673928 hasConceptScore W3215673928C58336856 @default.
- W3215673928 hasConceptScore W3215673928C71924100 @default.
- W3215673928 hasConceptScore W3215673928C84393581 @default.
- W3215673928 hasIssue "Suppl_1" @default.
- W3215673928 hasLocation W32156739281 @default.
- W3215673928 hasOpenAccess W3215673928 @default.
- W3215673928 hasPrimaryLocation W32156739281 @default.
- W3215673928 hasRelatedWork W1561198074 @default.
- W3215673928 hasRelatedWork W1575135201 @default.
- W3215673928 hasRelatedWork W1967473642 @default.
- W3215673928 hasRelatedWork W2020274782 @default.
- W3215673928 hasRelatedWork W2117062737 @default.
- W3215673928 hasRelatedWork W3174715237 @default.
- W3215673928 hasRelatedWork W3175659819 @default.
- W3215673928 hasRelatedWork W3215673928 @default.
- W3215673928 hasRelatedWork W4286852030 @default.
- W3215673928 hasRelatedWork W4321004360 @default.
- W3215673928 hasVolume "144" @default.
- W3215673928 isParatext "false" @default.
- W3215673928 isRetracted "false" @default.
- W3215673928 magId "3215673928" @default.
- W3215673928 workType "article" @default.