FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215694468> ?p ?o ?g. }

• W3215694468 endingPage "924" @default.
• W3215694468 startingPage "859" @default.
• W3215694468 abstract "Genetically engineered animals enable the study of gene function and disease pathophysiology in efficient, precise, and complex ways. Detailed genomic information for numerous laboratory mouse and rat strains is in the public domain, and international, multilaboratory consortia have made significant headway in characterizing the phenotypic outcomes of mutating every protein-encoding gene in the mouse. The number of engineered models resulting from random insertion as well as targeted deletion or replacement of specific genes is ever expanding. The discovery and development of new products, especially medical therapies, rely on genetically modified animal models to define new targets, elucidate mechanisms of disease and toxicity, and screen products for efficacy and safety. Engineered models for use in drug development include mouse models of human metabolism, mouse models for mutagenicity testing and carcinogenicity assessment, and genetically immunodeficient mice and rats that support the growth of human tissue xenografts suitable for in vivo studies of cancer treatments and nonclinical safety assessment of human cell-based products. Genetically engineered livestock are used as bioreactors to produce therapeutic proteins (“biopharming”); as donors for cell, organ, and tissue xenotransplantation; and increasingly as a source of food products. Toxicologic pathology assessments of genetically modified animals and their products employ the same endpoints that are used in conventional nonclinical safety assessment studies for biomolecules, chemicals, drugs, and cell products. Additional factors that must be considered when analyzing genetically engineered animals include knowledge of the induced mutation and the caveats of the method used in generating a given model, the potential for species-specific molecular mechanisms (where the responses of animals to inserted human gene products often do not recapitulate the human responses), and the possible introduction and propagation of animal pathogens into humans by xenografting infected cells or organs." @default.
• W3215694468 created "2021-12-06" @default.
• W3215694468 creator A5011929463 @default.
• W3215694468 creator A5050489906 @default.
• W3215694468 creator A5053453958 @default.
• W3215694468 creator A5089506793 @default.
• W3215694468 date "2022-01-01" @default.
• W3215694468 modified "2023-09-23" @default.
• W3215694468 title "Genetically Engineered Animal Models in Toxicologic Research" @default.
• W3215694468 cites W1416422246 @default.
• W3215694468 cites W1484035337 @default.
• W3215694468 cites W1547667831 @default.
• W3215694468 cites W1596984737 @default.
• W3215694468 cites W1768014335 @default.
• W3215694468 cites W1961283177 @default.
• W3215694468 cites W1963563607 @default.
• W3215694468 cites W1965606192 @default.
• W3215694468 cites W1966153481 @default.
• W3215694468 cites W1968458490 @default.
• W3215694468 cites W1969144409 @default.
• W3215694468 cites W1972187551 @default.
• W3215694468 cites W1973770839 @default.
• W3215694468 cites W1974752732 @default.
• W3215694468 cites W1976199077 @default.
• W3215694468 cites W1976507427 @default.
• W3215694468 cites W1977229182 @default.
• W3215694468 cites W1978865111 @default.
• W3215694468 cites W1981878585 @default.
• W3215694468 cites W1982034413 @default.
• W3215694468 cites W1985144041 @default.
• W3215694468 cites W1988524793 @default.
• W3215694468 cites W1989578731 @default.
• W3215694468 cites W1990084184 @default.
• W3215694468 cites W1990992825 @default.
• W3215694468 cites W1995765796 @default.
• W3215694468 cites W1998782859 @default.
• W3215694468 cites W2000780919 @default.
• W3215694468 cites W2001679453 @default.
• W3215694468 cites W2001685483 @default.
• W3215694468 cites W2001962483 @default.
• W3215694468 cites W2002027167 @default.
• W3215694468 cites W2003921075 @default.
• W3215694468 cites W2004007960 @default.
• W3215694468 cites W2005061481 @default.
• W3215694468 cites W2009453784 @default.
• W3215694468 cites W2009603525 @default.
• W3215694468 cites W2014062252 @default.
• W3215694468 cites W2017135498 @default.
• W3215694468 cites W2019171406 @default.
• W3215694468 cites W2020236947 @default.
• W3215694468 cites W2021010307 @default.
• W3215694468 cites W2024191382 @default.
• W3215694468 cites W2026599956 @default.
• W3215694468 cites W2028783555 @default.
• W3215694468 cites W2032570745 @default.
• W3215694468 cites W2034127787 @default.
• W3215694468 cites W2035266338 @default.
• W3215694468 cites W2037755687 @default.
• W3215694468 cites W2041515126 @default.
• W3215694468 cites W2044617562 @default.
• W3215694468 cites W2044703739 @default.
• W3215694468 cites W2046569255 @default.
• W3215694468 cites W2047681783 @default.
• W3215694468 cites W2050255961 @default.
• W3215694468 cites W2050302632 @default.
• W3215694468 cites W2052503785 @default.
• W3215694468 cites W2052966992 @default.
• W3215694468 cites W2054750356 @default.
• W3215694468 cites W2054963453 @default.
• W3215694468 cites W2055091962 @default.
• W3215694468 cites W2055857311 @default.
• W3215694468 cites W2057687465 @default.
• W3215694468 cites W2059124791 @default.
• W3215694468 cites W2059304159 @default.
• W3215694468 cites W2060890963 @default.
• W3215694468 cites W2061184966 @default.
• W3215694468 cites W2068190035 @default.
• W3215694468 cites W2073262404 @default.
• W3215694468 cites W2076073116 @default.
• W3215694468 cites W2076772756 @default.
• W3215694468 cites W2078327940 @default.
• W3215694468 cites W2078528462 @default.
• W3215694468 cites W2080114744 @default.
• W3215694468 cites W2082137006 @default.
• W3215694468 cites W2082748295 @default.
• W3215694468 cites W2086280068 @default.
• W3215694468 cites W2088308231 @default.
• W3215694468 cites W2090437073 @default.
• W3215694468 cites W2091696067 @default.
• W3215694468 cites W2093294267 @default.
• W3215694468 cites W2093405242 @default.
• W3215694468 cites W2094346533 @default.
• W3215694468 cites W2097481396 @default.
• W3215694468 cites W2102349785 @default.
• W3215694468 cites W2103226619 @default.
• W3215694468 cites W2104088897 @default.
• W3215694468 cites W2104604857 @default.
• W3215694468 cites W2109436824 @default.

• next