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• W3215702204 abstract "In the present work, nanoparticles of previously synthesized 3a derivatives of vanillic acid were synthesized by the nanoprecipitation method. Nanoparticles were further characterized by UV–vis spectroscopy, FTIR spectroscopy, SEM analysis, XRD and zeta sizer. Diabetes was instigated in Wistar albino rats by intraperitoneal (I.P.) administration of Streptozotocin (60 ​mg/kg body weight). Vanillic acid (100 ​mg/kg), 3a (100 ​mg/kg) and 3aNPs (50 ​mg/kg) body weight were given orally for a period of 21 days. Blood glucose level and biochemical parameters such as cholesterol, triglycerides, LDL, HDL, VLDL and antioxidant parameters were assessed by using diagnostic kits. SEM analysis and PDI of 3aNPs was found to be 0.2 which indicate monodisperse distribution. Significant decline in blood glucose level (p ​< ​0.001) was observed in antidiabetic studies along with the lipid lowering and antioxidant effect in dose-dependent manner. The noted results of the study showed that nanoparticles were found to be effective in treating diabetes." @default.
• W3215702204 created "2021-12-06" @default.
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• W3215702204 date "2022-01-01" @default.
• W3215702204 modified "2023-09-26" @default.
• W3215702204 title "Nano-formulation of 4-Hydroxy-3-methoxybenzohydrazide: Preparation, characterization and studies of antihyperglycemic and antioxidant activities as evaluated through amelioration of pancreatic Dysfunction in experimental animals" @default.
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• W3215702204 doi "https://doi.org/10.1016/j.jics.2021.100282" @default.
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