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- W3215703717 abstract "Cardiolipin is a tetra-acylated di-phosphatidylglycerol lipid enriched in the matrix facing (inner) leaflet of the mitochondrial inner membrane. Cardiolipin plays an important role in regulating mitochondria function and dynamics. Yet, the mechanisms connecting cardiolipin distribution and mitochondrial protein function remain indirect. In our previous work, we established an in vitro system reconstituting mitochondrial inner membrane fusion mediated by Opa1. We found that the long form of Opa1 (l-Opa1) works together with the proteolytically processed short form (s-Opa1) to mediate fast and efficient membrane fusion. Here, we extend our reconstitution system to generate supported lipid bilayers with asymmetric CL distribution. Using this system, we find the presence of CL on the intermembrane space-facing (outer) leaflet is important for membrane tethering and fusion. We discuss how the presence of CL in this leaflet may influence protein and membrane properties, and future applications for this approach." @default.
- W3215703717 created "2021-12-06" @default.
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- W3215703717 date "2021-09-02" @default.
- W3215703717 modified "2023-10-16" @default.
- W3215703717 title "Absence of cardiolipin from the mitochondrial inner membrane outer leaflet restricts Opa1-mediated fusion" @default.
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- W3215703717 doi "https://doi.org/10.1101/2021.09.01.458556" @default.
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