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• W3215704212 abstract "<b>Background:</b> Airflow obstruction (FEV₁/FVC ratio <0.7) is associated with increased lung function decline and exacerbation frequency in asthma. It is often considered irreversible. <b>Aim:</b> Analyse the impact of treatment escalation on airflow obstruction in asthma. <b>Methods:</b> CAPTAIN: Phase IIIA, randomised, double-blind, 24–52-week, parallel-group study in adults with uncontrolled asthma. Run-in/stabilisation: 3 weeks fluticasone propionate/salmeterol (250/50µg; DISKUS) BID followed by 2 weeks FF/VI (100/25µg; ELLIPTA) QD. Randomisation: FF/VI (100/25, 200/25μg) or FF/UMEC/VI (100/31.25/25, 100/62.5/25, 200/31.25/25, 200/62.5/25μg) QD (ELLIPTA). Outcomes: proportion of patients with pre-bronchodilator FEV₁/FVC ≥0.7 at screening and randomisation, shift in FEV₁/FVC from <0.7 at randomisation to ≥0.7 at Week 24 by treatment group (post hoc analysis). Only data for UMEC 62.5μg are shown. <b>Results:</b> The proportion of the total population with FEV₁/FVC ≥0.7 increased from 24% (579/2423) at screening to 36% (867/2420) at randomisation. The proportion of patients with FEV₁/FVC <0.7 at randomisation who shifted to FEV₁/FVC ≥0.7 at Week 24 was higher in the FF/UMEC/VI 100/62.5/25 vs FF/VI 100/25 treatment group (13 vs 8%), and in the FF/UMEC/VI 200/62.5/25 vs FF/VI 200/25 treatment group (21 vs 11%) (<b>Fig</b>). <b>Conclusions:</b> Airflow obstruction may be reversible with treatment escalation in some patients with asthma. <b>Funding:</b> GSK (205715/NCT02924688)." @default.
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• W3215704212 date "2021-09-05" @default.
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• W3215704212 title "CAPTAIN: Improvements in airflow obstruction in patients with uncontrolled asthma" @default.
• W3215704212 doi "https://doi.org/10.1183/13993003.congress-2021.pa3383" @default.
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