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• W3215705467 abstract "ABSTRACT SARS-CoV-2 infection is mediated by the entry receptor ACE2. Although attachment factors and co-receptors facilitating entry are extensively studied, cellular entry factors inhibiting viral entry are largely unknown. Using a surface ome CRISPR activation screen, we identified human LRRC15 as an inhibitory receptor for SARS-CoV-2 entry. LRRC15 directly binds to the receptor-binding domain (RBD) of spike protein with a moderate affinity and inhibits spike-mediated entry. Analysis of human lung single cell RNA sequencing dataset reveals that expression of LRRC15 is primarily detected in fibroblasts and particularly enriched in pathological fibroblasts in COVID-19 patients. ACE2 and LRRC15 are not co-expressed in the same cell types in the lung. Strikingly, expression of LRRC15 in ACE2-negative cells blocks spike-mediated viral entry in ACE2+ cell in trans , suggesting a protective role of LRRC15 in a physiological context. Therefore, LRRC15 represents an inhibitory receptor for SARS-CoV-2 regulating viral entry in trans ." @default.
• W3215705467 created "2021-12-06" @default.
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• W3215705467 date "2021-11-24" @default.
• W3215705467 modified "2023-10-17" @default.
• W3215705467 title "LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry <i>in trans</i>" @default.
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• W3215705467 doi "https://doi.org/10.1101/2021.11.23.469714" @default.
• W3215705467 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8629192" @default.
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