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- W3215722904 abstract "The enzymatic modification of phenolic molecules to higher molecular weight compounds is a promising approach for improving biological activity. In the current study, the Trametes pubescens laccase was used to modify isorhamnetin (m/z 315) as a way of improving its antioxidant and antibacterial activities. Using a monophasic system with ethanol as co-solvent, laccase-catalysed oxidation of isorhamnetin produced a dimer, IP1 (m/z 629, yield 28.8 %) and an unidentified product, IP2 (m/z 457, yield 21.8 %). The dimer showed twice the antioxidant capacity of isorhamnetin, while the unidentified product IP2 was less active than isorhamnetin. Listeria monocytogenes and methicillin-resistant Staphylococcus aureus showed susceptibility to IP1 (minimum inhibitory concentration two times lower compared to isorhamnetin), while Pseudomonas aeruginosa was susceptible to IP2 (minimum inhibitory concentration two times lower compared to isorhamnetin). Both oxidation products showed a bactericidal mode of action; membrane destruction was evidenced by loss of cell constituents in cell integrity assays, and by cell pores and fragmentations observed in scanning electron microscopy images. The dimer had improved antioxidant and antibacterial activities and may be exploited for nutraceutical purposes and in other relevant industries. The product IP2 may also be useful in the treatment of Gram-negative infections associated with P. aeruginosa." @default.
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- W3215722904 date "2022-01-01" @default.
- W3215722904 modified "2023-10-17" @default.
- W3215722904 title "Laccase-mediated modification of isorhamnetin improves antioxidant and antibacterial activities" @default.
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- W3215722904 doi "https://doi.org/10.1016/j.procbio.2021.11.019" @default.
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