FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215730582> ?p ?o ?g. }

• W3215730582 endingPage "131" @default.
• W3215730582 startingPage "120" @default.
• W3215730582 abstract "BACKGROUND. Multiple sclerosis (MS) is characterized by both acute and chronic intrathecal inflammation. A subset of MS lesions show paramagnetic rims on susceptibility-weighted MRI sequences, reflecting iron accumulation in microglia. These para-magnetic rim lesions have been proposed as a marker of compartmentalized smoldering disease. Paramagnetic rim lesions have been shown at 7 T and, more recently, at 3 T. As susceptibility effects are weaker at lower field strength, it remains unclear if paramagnetic rim lesions are visible at 1.5 T. OBJECTIVE. The purpose of our study was to compare visualization of paramagnetic rim lesions using susceptibility-weighted imaging at 1.5-T and 3-T MRI in patients with MS. METHODS. This retrospective study included nine patients (five women, four men; mean age, 46.8 years) with MS who underwent both 1.5-T and 3-T MRI using a comparable susceptibility-weighted angiography (SWAN) sequence from the same manufacturer. Lesions measuring greater than 3 mm were annotated. Two reviewers independently assessed images at each field strength in separate sessions and classified the annotated lesions as isointense, diffusely paramagnetic, or paramagnetic rim lesions. Discrepancies were discussed at consensus sessions including a third reviewer. Agreement was assessed using kappa coefficients. RESULTS. Based on the 3-T consensus readings, 115 of 140 annotated lesions (82%) were isointense lesions, 16 (11%) were diffusely paramagnetic lesions, and nine (6%) were paramagnetic rim lesions; based on the 1.5-T consensus readings, 115 (82%) were isointense lesions, 14 (10%) were diffusely paramagnetic lesions, and 11 (8%) were para-magnetic rim lesions. The mean lesion diameter was 11.9 mm for paramagnetic rim lesions versus 6.4 mm for diffusely paramagnetic lesions (p = .006) and 7.8 mm for iso-intense lesions (p = .003). Interrater agreement for lesion classification as a paramagnetic rim lesion was substantial at 1.5 T (κ = 0.65) and 3 T (κ = 0.70). Agreement for paramagnetic rim lesions was also substantial between the consensus readings at the two field strengths (κ = 0.79). CONCLUSION. We show comparable identification of paramagnetic rim lesions at 1.5-T and 3-T MRI with substantial interrater agreement at both field strengths and substantial consensus agreement between the field strengths. CLINICAL IMPACT. Paramagnetic rim lesions may be an emerging marker of chronic neuroinflammation in MS. Their visibility at 1.5 T supports the translational potential of paramagnetic rim lesion identification to more widespread clinical settings, where 1.5-T scanners are prevalent." @default.
• W3215730582 created "2021-12-06" @default.
• W3215730582 creator A5013292054 @default.
• W3215730582 creator A5024904743 @default.
• W3215730582 creator A5030695455 @default.
• W3215730582 date "2022-07-01" @default.
• W3215730582 modified "2023-10-01" @default.
• W3215730582 title "Paramagnetic Rim Lesions in Multiple Sclerosis: Comparison of Visualization at 1.5-T and 3-T MRI" @default.
• W3215730582 cites W1578762211 @default.
• W3215730582 cites W1862436065 @default.
• W3215730582 cites W1979911585 @default.
• W3215730582 cites W2051933121 @default.
• W3215730582 cites W2112165124 @default.
• W3215730582 cites W2118060850 @default.
• W3215730582 cites W2121588703 @default.
• W3215730582 cites W2127890285 @default.
• W3215730582 cites W2154189431 @default.
• W3215730582 cites W2164777277 @default.
• W3215730582 cites W2290321704 @default.
• W3215730582 cites W2419062639 @default.
• W3215730582 cites W2542350582 @default.
• W3215730582 cites W2551398945 @default.
• W3215730582 cites W2777074421 @default.
• W3215730582 cites W2801689542 @default.
• W3215730582 cites W2890238467 @default.
• W3215730582 cites W2967069002 @default.
• W3215730582 cites W3014367256 @default.
• W3215730582 cites W3026848541 @default.
• W3215730582 cites W3049268149 @default.
• W3215730582 cites W3124374877 @default.
• W3215730582 cites W3134905845 @default.
• W3215730582 cites W3197136220 @default.
• W3215730582 cites W4253381763 @default.
• W3215730582 doi "https://doi.org/10.2214/ajr.21.26777" @default.
• W3215730582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34851712" @default.
• W3215730582 hasPublicationYear "2022" @default.
• W3215730582 type Work @default.
• W3215730582 sameAs 3215730582 @default.
• W3215730582 citedByCount "13" @default.
• W3215730582 countsByYear W32157305822022 @default.
• W3215730582 countsByYear W32157305822023 @default.
• W3215730582 crossrefType "journal-article" @default.
• W3215730582 hasAuthorship W3215730582A5013292054 @default.
• W3215730582 hasAuthorship W3215730582A5024904743 @default.
• W3215730582 hasAuthorship W3215730582A5030695455 @default.
• W3215730582 hasBestOaLocation W32157305822 @default.
• W3215730582 hasConcept C118552586 @default.
• W3215730582 hasConcept C121332964 @default.
• W3215730582 hasConcept C124712363 @default.
• W3215730582 hasConcept C126838900 @default.
• W3215730582 hasConcept C142724271 @default.
• W3215730582 hasConcept C143409427 @default.
• W3215730582 hasConcept C2780640218 @default.
• W3215730582 hasConcept C2989005 @default.
• W3215730582 hasConcept C62520636 @default.
• W3215730582 hasConcept C71924100 @default.
• W3215730582 hasConceptScore W3215730582C118552586 @default.
• W3215730582 hasConceptScore W3215730582C121332964 @default.
• W3215730582 hasConceptScore W3215730582C124712363 @default.
• W3215730582 hasConceptScore W3215730582C126838900 @default.
• W3215730582 hasConceptScore W3215730582C142724271 @default.
• W3215730582 hasConceptScore W3215730582C143409427 @default.
• W3215730582 hasConceptScore W3215730582C2780640218 @default.
• W3215730582 hasConceptScore W3215730582C2989005 @default.
• W3215730582 hasConceptScore W3215730582C62520636 @default.
• W3215730582 hasConceptScore W3215730582C71924100 @default.
• W3215730582 hasIssue "1" @default.
• W3215730582 hasLocation W32157305821 @default.
• W3215730582 hasLocation W32157305822 @default.
• W3215730582 hasLocation W32157305823 @default.
• W3215730582 hasOpenAccess W3215730582 @default.
• W3215730582 hasPrimaryLocation W32157305821 @default.
• W3215730582 hasRelatedWork W1965705486 @default.
• W3215730582 hasRelatedWork W2005020945 @default.
• W3215730582 hasRelatedWork W2008582965 @default.
• W3215730582 hasRelatedWork W2040286508 @default.
• W3215730582 hasRelatedWork W2051663530 @default.
• W3215730582 hasRelatedWork W2150012525 @default.
• W3215730582 hasRelatedWork W2415370538 @default.
• W3215730582 hasRelatedWork W2420354499 @default.
• W3215730582 hasRelatedWork W2617222556 @default.
• W3215730582 hasRelatedWork W2618644874 @default.
• W3215730582 hasVolume "219" @default.
• W3215730582 isParatext "false" @default.
• W3215730582 isRetracted "false" @default.
• W3215730582 magId "3215730582" @default.
• W3215730582 workType "article" @default.