Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215736953> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3215736953 endingPage "e056436" @default.
- W3215736953 startingPage "e056436" @default.
- W3215736953 abstract "Patients treated with long-term opioid therapy (LTOT) are known to have compromised immune systems and respiratory function, both of which make them particularly susceptible to the SARS-CoV-2 virus. The objective of this study was to assess the risk of developing severe clinical outcomes among COVID-19 non-cancer patients on LTOT, compared with those without LTOT.A retrospective cohort design using electronic health records in the TriNetX research database.418 216 adults diagnosed with COVID-19 in January-December 2020 from 51 US healthcare organisations: 9558 in the LTOT and 408 658 in the control cohort. They did not have cancer diagnoses; only a small proportion might have been treated with opioid maintenance for opioid use disorder.Patient on LTOT had a higher risk ratio (RR) than control patients to visit an emergency department (RR 2.04, 95% CI 1.93 to 2.16) and be hospitalised (RR 2.91, 95% CI 2.69 to 3.15). Once admitted, LTOT patients were more likely to require intensive care (RR 3.65, 95% CI 3.10 to 4.29), mechanical ventilation (RR 3.47, 95% CI 2.89 to 4.15) and vasopressor support (RR 5.28, 95% CI 3.70 to 7.53) and die within 30 days (RR 1.96, 95% CI 1.67 to 2.30). The LTOT group also showed increased risk (RRs from 2.06 to 3.98, all significant to 95% CI) of more-severe infection (eg, cough, dyspnoea, fever, hypoxaemia, thrombocytopaenia and acute respiratory distress syndrome). Statistically significant differences in several laboratory results and other vital signs appeared clinically negligible.COVID-19 patients on LTOT were at higher risk of increased morbidity, mortality and healthcare utilisation. Interventions to reduce the need for LTOT and to increase compliance with COVID-19 protective measures may improve outcomes and reduce healthcare cost in this population. Prospective studies need to confirm and refine these findings." @default.
- W3215736953 created "2021-12-06" @default.
- W3215736953 creator A5021023843 @default.
- W3215736953 creator A5059728091 @default.
- W3215736953 creator A5077944727 @default.
- W3215736953 creator A5082865739 @default.
- W3215736953 date "2021-11-01" @default.
- W3215736953 modified "2023-09-25" @default.
- W3215736953 title "COVID-19 outcomes among adult patients treated with long-term opioid therapy for chronic non-cancer pain in the USA: a retrospective cohort study" @default.
- W3215736953 cites W1972242861 @default.
- W3215736953 cites W1990355279 @default.
- W3215736953 cites W2132468342 @default.
- W3215736953 cites W2163278718 @default.
- W3215736953 cites W2168752673 @default.
- W3215736953 cites W2742752821 @default.
- W3215736953 cites W2787483926 @default.
- W3215736953 cites W2803559780 @default.
- W3215736953 cites W2808161878 @default.
- W3215736953 cites W2912153459 @default.
- W3215736953 cites W2959866546 @default.
- W3215736953 cites W3010813076 @default.
- W3215736953 cites W3014294089 @default.
- W3215736953 cites W3025405166 @default.
- W3215736953 cites W3025937663 @default.
- W3215736953 cites W3029616546 @default.
- W3215736953 cites W3036453504 @default.
- W3215736953 cites W3041809950 @default.
- W3215736953 cites W3042839868 @default.
- W3215736953 cites W3045130304 @default.
- W3215736953 cites W3048557429 @default.
- W3215736953 cites W3080517202 @default.
- W3215736953 cites W3086642606 @default.
- W3215736953 cites W3087377819 @default.
- W3215736953 cites W3095229830 @default.
- W3215736953 cites W3117788251 @default.
- W3215736953 cites W3125996955 @default.
- W3215736953 cites W3129458625 @default.
- W3215736953 cites W3132840599 @default.
- W3215736953 cites W3134535654 @default.
- W3215736953 cites W3201145434 @default.
- W3215736953 doi "https://doi.org/10.1136/bmjopen-2021-056436" @default.
- W3215736953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8628115" @default.
- W3215736953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34836910" @default.
- W3215736953 hasPublicationYear "2021" @default.
- W3215736953 type Work @default.
- W3215736953 sameAs 3215736953 @default.
- W3215736953 citedByCount "13" @default.
- W3215736953 countsByYear W32157369532022 @default.
- W3215736953 countsByYear W32157369532023 @default.
- W3215736953 crossrefType "journal-article" @default.
- W3215736953 hasAuthorship W3215736953A5021023843 @default.
- W3215736953 hasAuthorship W3215736953A5059728091 @default.
- W3215736953 hasAuthorship W3215736953A5077944727 @default.
- W3215736953 hasAuthorship W3215736953A5082865739 @default.
- W3215736953 hasBestOaLocation W32157369531 @default.
- W3215736953 hasConcept C126322002 @default.
- W3215736953 hasConcept C167135981 @default.
- W3215736953 hasConcept C187212893 @default.
- W3215736953 hasConcept C201903717 @default.
- W3215736953 hasConcept C2777080012 @default.
- W3215736953 hasConcept C44249647 @default.
- W3215736953 hasConcept C71924100 @default.
- W3215736953 hasConcept C72563966 @default.
- W3215736953 hasConcept C82789193 @default.
- W3215736953 hasConceptScore W3215736953C126322002 @default.
- W3215736953 hasConceptScore W3215736953C167135981 @default.
- W3215736953 hasConceptScore W3215736953C187212893 @default.
- W3215736953 hasConceptScore W3215736953C201903717 @default.
- W3215736953 hasConceptScore W3215736953C2777080012 @default.
- W3215736953 hasConceptScore W3215736953C44249647 @default.
- W3215736953 hasConceptScore W3215736953C71924100 @default.
- W3215736953 hasConceptScore W3215736953C72563966 @default.
- W3215736953 hasConceptScore W3215736953C82789193 @default.
- W3215736953 hasIssue "11" @default.
- W3215736953 hasLocation W32157369531 @default.
- W3215736953 hasLocation W32157369532 @default.
- W3215736953 hasLocation W32157369533 @default.
- W3215736953 hasLocation W32157369534 @default.
- W3215736953 hasOpenAccess W3215736953 @default.
- W3215736953 hasPrimaryLocation W32157369531 @default.
- W3215736953 hasRelatedWork W1971557041 @default.
- W3215736953 hasRelatedWork W1980275360 @default.
- W3215736953 hasRelatedWork W2090822315 @default.
- W3215736953 hasRelatedWork W2157077459 @default.
- W3215736953 hasRelatedWork W2754539770 @default.
- W3215736953 hasRelatedWork W2792210947 @default.
- W3215736953 hasRelatedWork W2912297585 @default.
- W3215736953 hasRelatedWork W2937211356 @default.
- W3215736953 hasRelatedWork W4312780918 @default.
- W3215736953 hasRelatedWork W2563600304 @default.
- W3215736953 hasVolume "11" @default.
- W3215736953 isParatext "false" @default.
- W3215736953 isRetracted "false" @default.
- W3215736953 magId "3215736953" @default.
- W3215736953 workType "article" @default.