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- W3215740171 abstract "Mechanobiology describes how the physical forces and mechanical properties of biological material contribute to physiology and disease. Typically, these approaches are limited single molecule methods, which restricts their availability. To address this need, a microplate assay was developed that enables mechanical manipulation while performing standard biochemical assays. This is achieved using magnets incorporated into a microplate lid to create multiple magnetic tweezers. In this format, force is exerted across biomolecules connected to paramagnetic beads, equivalent to a typical magnetic tweezer. The study demonstrates the application of this tool with FRET-based assays to monitor protein conformations. However, this approach is widely applicable to different biological systems ranging from measuring enzymatic activity through to the activation of signaling pathways in live cells." @default.
- W3215740171 created "2021-12-06" @default.
- W3215740171 creator A5026385772 @default.
- W3215740171 creator A5051163780 @default.
- W3215740171 date "2021-09-08" @default.
- W3215740171 modified "2023-09-27" @default.
- W3215740171 title "Magnetic tweezers in a microplate format" @default.
- W3215740171 hasPublicationYear "2021" @default.
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