FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215741251> ?p ?o ?g. }

• W3215741251 abstract "We study the potential for the de novo evolution of genes from random nucleotide sequences using libraries of E. coli expressing random sequence peptides. We assess the effects of such peptides on cell growth by monitoring frequency changes of individual clones in a complex library through four serial passages. Using a new analysis pipeline that allows to trace peptides of all lengths, we find that over half of the peptides have consistent effects on cell growth. Across nine different experiments, around 16 % of clones increase in frequency and 36 % decrease, with some variation between individual experiments. Shorter peptides (8 - 20 residues), are more likely to increase in frequency, longer ones are more likely to decrease. GC content, amino acid composition, intrinsic dis-order and aggregation propensity show slightly different patterns between peptide groups. Sequences that increase in frequency tend to be more disordered with lower aggregation propensity. This coincides with the observation that young genes with more disordered structures are better tolerated in genomes. Our data indicate that random sequences can be a source of evolutionary innovation, since a large fraction of them are well tolerated by the cells or can provide a growth advantage." @default.
• W3215741251 created "2021-12-06" @default.
• W3215741251 creator A5018355185 @default.
• W3215741251 creator A5074801390 @default.
• W3215741251 date "2021-11-23" @default.
• W3215741251 modified "2023-10-15" @default.
• W3215741251 title "The effects of sequence length and composition of random sequence peptides on the growth of E. coli cells" @default.
• W3215741251 cites W1551404386 @default.
• W3215741251 cites W1902451327 @default.
• W3215741251 cites W1978429934 @default.
• W3215741251 cites W1996423252 @default.
• W3215741251 cites W2009165504 @default.
• W3215741251 cites W2018431595 @default.
• W3215741251 cites W2050115925 @default.
• W3215741251 cites W2057844822 @default.
• W3215741251 cites W2059223767 @default.
• W3215741251 cites W2059908311 @default.
• W3215741251 cites W2080831965 @default.
• W3215741251 cites W2086633865 @default.
• W3215741251 cites W2087923822 @default.
• W3215741251 cites W2097484079 @default.
• W3215741251 cites W2120167569 @default.
• W3215741251 cites W2120507610 @default.
• W3215741251 cites W2124351063 @default.
• W3215741251 cites W2127673162 @default.
• W3215741251 cites W2129883957 @default.
• W3215741251 cites W2141124151 @default.
• W3215741251 cites W2160919518 @default.
• W3215741251 cites W2161153002 @default.
• W3215741251 cites W2179438025 @default.
• W3215741251 cites W2263564668 @default.
• W3215741251 cites W2294611355 @default.
• W3215741251 cites W2601961903 @default.
• W3215741251 cites W2608157918 @default.
• W3215741251 cites W2609769603 @default.
• W3215741251 cites W2735379537 @default.
• W3215741251 cites W2750286977 @default.
• W3215741251 cites W2767444993 @default.
• W3215741251 cites W2805188346 @default.
• W3215741251 cites W2806354673 @default.
• W3215741251 cites W2806879747 @default.
• W3215741251 cites W2806884808 @default.
• W3215741251 cites W2889723071 @default.
• W3215741251 cites W2899373020 @default.
• W3215741251 cites W2945066961 @default.
• W3215741251 cites W2948098754 @default.
• W3215741251 cites W2950550152 @default.
• W3215741251 cites W2969287734 @default.
• W3215741251 cites W3004726194 @default.
• W3215741251 cites W3014506894 @default.
• W3215741251 cites W3014888669 @default.
• W3215741251 cites W3097658527 @default.
• W3215741251 cites W3118835475 @default.
• W3215741251 cites W3118982697 @default.
• W3215741251 cites W3216050312 @default.
• W3215741251 doi "https://doi.org/10.1101/2021.11.22.469569" @default.
• W3215741251 hasPublicationYear "2021" @default.
• W3215741251 type Work @default.
• W3215741251 sameAs 3215741251 @default.
• W3215741251 citedByCount "1" @default.
• W3215741251 countsByYear W32157412512021 @default.
• W3215741251 crossrefType "posted-content" @default.
• W3215741251 hasAuthorship W3215741251A5018355185 @default.
• W3215741251 hasAuthorship W3215741251A5074801390 @default.
• W3215741251 hasBestOaLocation W32157412511 @default.
• W3215741251 hasConcept C104317684 @default.
• W3215741251 hasConcept C138885662 @default.
• W3215741251 hasConcept C141231307 @default.
• W3215741251 hasConcept C167625842 @default.
• W3215741251 hasConcept C2778112365 @default.
• W3215741251 hasConcept C2779281246 @default.
• W3215741251 hasConcept C40231798 @default.
• W3215741251 hasConcept C41895202 @default.
• W3215741251 hasConcept C515207424 @default.
• W3215741251 hasConcept C54355233 @default.
• W3215741251 hasConcept C55493867 @default.
• W3215741251 hasConcept C70721500 @default.
• W3215741251 hasConcept C86803240 @default.
• W3215741251 hasConceptScore W3215741251C104317684 @default.
• W3215741251 hasConceptScore W3215741251C138885662 @default.
• W3215741251 hasConceptScore W3215741251C141231307 @default.
• W3215741251 hasConceptScore W3215741251C167625842 @default.
• W3215741251 hasConceptScore W3215741251C2778112365 @default.
• W3215741251 hasConceptScore W3215741251C2779281246 @default.
• W3215741251 hasConceptScore W3215741251C40231798 @default.
• W3215741251 hasConceptScore W3215741251C41895202 @default.
• W3215741251 hasConceptScore W3215741251C515207424 @default.
• W3215741251 hasConceptScore W3215741251C54355233 @default.
• W3215741251 hasConceptScore W3215741251C55493867 @default.
• W3215741251 hasConceptScore W3215741251C70721500 @default.
• W3215741251 hasConceptScore W3215741251C86803240 @default.
• W3215741251 hasLocation W32157412511 @default.
• W3215741251 hasOpenAccess W3215741251 @default.
• W3215741251 hasPrimaryLocation W32157412511 @default.
• W3215741251 hasRelatedWork W1442603624 @default.
• W3215741251 hasRelatedWork W1995523102 @default.
• W3215741251 hasRelatedWork W2003922337 @default.
• W3215741251 hasRelatedWork W2069184423 @default.
• W3215741251 hasRelatedWork W2110447214 @default.
• W3215741251 hasRelatedWork W2151912589 @default.

• next