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• W3215741710 endingPage "101466" @default.
• W3215741710 startingPage "101466" @default.
• W3215741710 abstract "Complex biological functions within organisms are frequently orchestrated by systemic communication between tissues. In the model organism Caenorhabditis elegans, the pharyngeal and body wall neuromuscular junctions are two discrete structures that control feeding and locomotion, respectively. Separate, the well-defined neuromuscular circuits control these distinct tissues. Nonetheless, the emergent behaviors, feeding and locomotion, are coordinated to guarantee the efficiency of food intake. Here, we show that pharmacological hyperactivation of cholinergic transmission at the body wall muscle reduces the rate of pumping behavior. This was evidenced by a systematic screening of the effect of the cholinesterase inhibitor aldicarb on the rate of pharyngeal pumping on food in mutant worms. The screening revealed that the key determinants of the inhibitory effect of aldicarb on pharyngeal pumping are located at the body wall neuromuscular junction. In fact, the selective stimulation of the body wall muscle receptors with the agonist levamisole inhibited pumping in a lev-1-dependent fashion. Interestingly, this response was independent of unc-38, an alpha subunit of the nicotinic receptor classically expressed with lev-1 at the body wall muscle. This implies an uncharacterized lev-1-containing receptor underpins this effect. Overall, our results reveal that body wall cholinergic transmission not only controls locomotion but simultaneously inhibits feeding behavior." @default.
• W3215741710 created "2021-12-06" @default.
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• W3215741710 date "2022-01-01" @default.
• W3215741710 modified "2023-09-30" @default.
• W3215741710 title "Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans" @default.
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• W3215741710 doi "https://doi.org/10.1016/j.jbc.2021.101466" @default.
• W3215741710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34864060" @default.
• W3215741710 hasPublicationYear "2022" @default.
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