FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215741857> ?p ?o ?g. }

• W3215741857 abstract "Abstract Alzheimer’s disease (AD) is an age-dependent progressive neurodegenerative disorder and the most common cause of dementia. The treatment and prevention of AD present immense yet unmet needs. One of the hallmarks of AD is the formation of extracellular amyloid plaques in the brain, composed of amyloid-beta (Aβ) peptides. Multiple amyloid-targeting drug candidates have recently failed in clinical trials, which creates the necessity to focus also on alternative therapeutic strategies. One factor contributing to the development of AD is dysregulated copper metabolism, reflected in the intracellular copper deficit and excess extracellular copper levels. In the current study, we follow the widely accepted hypothesis that the normalization of copper metabolism leads to the prevention or slowing of the disease and searched for new copper-regulating ligands. We demonstrate that the natural intracellular copper chelator, α-lipoic acid (LA) translocates copper from extracellular to intracellular space in a SH-SY5Y-based neuronal cell model, and is thus suitable to alleviate the intracellular copper deficit characteristic of AD neurons. Furthermore, we show that supplementation with LA protects the Drosophila melanogaster model of AD from developing AD phenotype, reflecting in decreased locomotor activity. Collectively, these results provide evidence that LA has the potential to normalize copper metabolism in AD and supports the hypothesis that LA supplementation may serve as a promising cost-effective method for the prevention and/or treatment of AD. Significance statement Alzheimer’s disease (AD) is a major biomedical concern that requires novel effective prevention and treatment approaches. An early determinant of AD pathology is dysregulated copper metabolism, which initiates the amyloid cascade, induces oxidative stress and impairs the functioning of cellular copper proteins, all contributing to the development of neurodegeneration. We suggest that the natural copper chelator α-lipoic acid (LA) can normalize impaired copper metabolism in AD. We demonstrate that LA promotes the influx of copper into SH-SY5Y cells in a dose-dependent manner. Moreover, we show that LA alleviates the disease phenotype in a Drosophila melanogaster model of AD. Together with previously published data, these results support the hypothesis that LA has the potential for the prevention and treatment of AD." @default.
• W3215741857 created "2021-12-06" @default.
• W3215741857 creator A5014428425 @default.
• W3215741857 creator A5014821902 @default.
• W3215741857 creator A5015195013 @default.
• W3215741857 creator A5022152649 @default.
• W3215741857 creator A5022620962 @default.
• W3215741857 creator A5044378503 @default.
• W3215741857 creator A5052745345 @default.
• W3215741857 creator A5009376732 @default.
• W3215741857 date "2021-03-16" @default.
• W3215741857 modified "2023-10-10" @default.
• W3215741857 title "α-lipoic acid has the potential to normalize copper metabolism, which is dysregulated in Alzheimer’s disease" @default.
• W3215741857 cites W1597944986 @default.
• W3215741857 cites W1838272947 @default.
• W3215741857 cites W1847017938 @default.
• W3215741857 cites W1968210490 @default.
• W3215741857 cites W1968938847 @default.
• W3215741857 cites W1969041362 @default.
• W3215741857 cites W1983546909 @default.
• W3215741857 cites W1985092163 @default.
• W3215741857 cites W1987133102 @default.
• W3215741857 cites W1988519721 @default.
• W3215741857 cites W1990001011 @default.
• W3215741857 cites W1991625887 @default.
• W3215741857 cites W1993231460 @default.
• W3215741857 cites W2002023508 @default.
• W3215741857 cites W2002554762 @default.
• W3215741857 cites W2005534585 @default.
• W3215741857 cites W2009526570 @default.
• W3215741857 cites W2010398494 @default.
• W3215741857 cites W2016822949 @default.
• W3215741857 cites W2024544489 @default.
• W3215741857 cites W2027985355 @default.
• W3215741857 cites W2029614399 @default.
• W3215741857 cites W2032698104 @default.
• W3215741857 cites W2033772210 @default.
• W3215741857 cites W2038596813 @default.
• W3215741857 cites W2041230020 @default.
• W3215741857 cites W2041890833 @default.
• W3215741857 cites W2044627978 @default.
• W3215741857 cites W2052987925 @default.
• W3215741857 cites W2057436204 @default.
• W3215741857 cites W2066549709 @default.
• W3215741857 cites W2066551411 @default.
• W3215741857 cites W2072467039 @default.
• W3215741857 cites W2072516967 @default.
• W3215741857 cites W2079522949 @default.
• W3215741857 cites W2079861976 @default.
• W3215741857 cites W2080100823 @default.
• W3215741857 cites W2080728286 @default.
• W3215741857 cites W2082027220 @default.
• W3215741857 cites W2084174305 @default.
• W3215741857 cites W2086138798 @default.
• W3215741857 cites W2097623950 @default.
• W3215741857 cites W2103400963 @default.
• W3215741857 cites W2103440561 @default.
• W3215741857 cites W2109348594 @default.
• W3215741857 cites W2110643873 @default.
• W3215741857 cites W2113950441 @default.
• W3215741857 cites W2116005865 @default.
• W3215741857 cites W2123210492 @default.
• W3215741857 cites W2131181742 @default.
• W3215741857 cites W2134731819 @default.
• W3215741857 cites W2139911439 @default.
• W3215741857 cites W2156813826 @default.
• W3215741857 cites W2162711901 @default.
• W3215741857 cites W2164371651 @default.
• W3215741857 cites W2315760675 @default.
• W3215741857 cites W2329336071 @default.
• W3215741857 cites W2404450481 @default.
• W3215741857 cites W2480682612 @default.
• W3215741857 cites W2557796551 @default.
• W3215741857 cites W2599851926 @default.
• W3215741857 cites W2627073161 @default.
• W3215741857 cites W2749751342 @default.
• W3215741857 cites W2753691082 @default.
• W3215741857 cites W2754663667 @default.
• W3215741857 cites W2760547687 @default.
• W3215741857 cites W2765742180 @default.
• W3215741857 cites W2766388141 @default.
• W3215741857 cites W2768273061 @default.
• W3215741857 cites W2789238556 @default.
• W3215741857 cites W2790141679 @default.
• W3215741857 cites W2804632916 @default.
• W3215741857 cites W2808017704 @default.
• W3215741857 cites W2896056517 @default.
• W3215741857 cites W2905048585 @default.
• W3215741857 cites W2925037571 @default.
• W3215741857 cites W2931670833 @default.
• W3215741857 cites W2954613999 @default.
• W3215741857 cites W2960505072 @default.
• W3215741857 cites W2969551143 @default.
• W3215741857 cites W3003729733 @default.
• W3215741857 cites W3041052371 @default.
• W3215741857 cites W3112612557 @default.
• W3215741857 cites W3195223588 @default.
• W3215741857 cites W4244665513 @default.
• W3215741857 cites W4248078302 @default.
• W3215741857 cites W96912318 @default.

• next