FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215745906> ?p ?o ?g. }

• W3215745906 endingPage "614" @default.
• W3215745906 startingPage "609" @default.
• W3215745906 abstract "<b><i>Background:</i></b> Psoriasis is a chronic and systemic inflammatory disease with a loss of up to 5 life years, which is thought to be reduced by biologic treatment. Disease severity and eligibility for systemic treatment are often based on the cutaneous psoriasis area and severity index (PASI) with a cut-off of 10 in several European countries. However, it is unclear how well this cut-off reflects systemic inflammation and, consequently, the risk for the development of comorbidity. <b><i>Objectives:</i></b> (1) To assess whether specific PASI thresholds, in particular PASI 10, predict elevated biomarkers of systemic inflammation and cardiovascular risk on an individual patient level. (2) To assess the association of PASI and psoriatic arthritis with biomarkers of systemic inflammation and cardiovascular risk. <b><i>Methods:</i></b> Retrospective cross-sectional study of 72 psoriasis patients without systemic treatment. <b><i>Results:</i></b> Overall, 68, 42, and 50% of patients had cardiovascular risk level neutrophil-to-lymphocyte ratio (NLR), C-reactive protein, and elevated platelet-to-lymphocyte ratio (PLR) values, respectively. The respective positive predictive values of PASI 10 were 70, 45, and 70. The performance of the optimal PASI cut-offs according to the Youden index was similarly weak. Subgrouping of patients with a PASI below 10 did not result in a considerably improved reflection of systemic inflammation. PLR was significantly higher in patients with moderate-to-severe compared to mild psoriasis and significantly correlated with PASI in patients with a PASI above 2 (<i>r</i>_s = 0.266, <i>n</i> = 64). NLR was significantly higher in patients with psoriatic arthritis. <b><i>Conclusion:</i></b> Specific PASI thresholds were not well suited to predict elevated biomarkers of systemic inflammation and cardiovascular risk on an individual patient level. Therefore, PASI, and possibly other purely cutaneous measures, may not be ideal as stand-alone parameters to define disease severity and eligibility for systemic treatment. Our results are relevant for the ongoing discussion on the definition of psoriasis severity and eligibility for systemic treatment. Further research addressing the added value of a set of biomarkers of systemic inflammation in the assessment of psoriasis severity would be desirable." @default.
• W3215745906 created "2021-12-06" @default.
• W3215745906 creator A5002731519 @default.
• W3215745906 creator A5017523407 @default.
• W3215745906 date "2021-12-01" @default.
• W3215745906 modified "2023-10-18" @default.
• W3215745906 title "Evaluation of Psoriasis Area and Severity Index Thresholds as Proxies for Systemic Inflammation on an Individual Patient Level" @default.
• W3215745906 cites W1488789440 @default.
• W3215745906 cites W1515251814 @default.
• W3215745906 cites W1526387844 @default.
• W3215745906 cites W1569084902 @default.
• W3215745906 cites W1828616852 @default.
• W3215745906 cites W1927572201 @default.
• W3215745906 cites W1983469765 @default.
• W3215745906 cites W2050471245 @default.
• W3215745906 cites W2052522522 @default.
• W3215745906 cites W2057448387 @default.
• W3215745906 cites W2072500831 @default.
• W3215745906 cites W2128722360 @default.
• W3215745906 cites W2152262899 @default.
• W3215745906 cites W2471442028 @default.
• W3215745906 cites W2776513120 @default.
• W3215745906 cites W2788638288 @default.
• W3215745906 cites W2791228900 @default.
• W3215745906 cites W2795583931 @default.
• W3215745906 cites W2799473857 @default.
• W3215745906 cites W2800377815 @default.
• W3215745906 cites W2892749776 @default.
• W3215745906 cites W2902033804 @default.
• W3215745906 cites W2926949021 @default.
• W3215745906 cites W2949717647 @default.
• W3215745906 cites W2952275419 @default.
• W3215745906 cites W2996336248 @default.
• W3215745906 cites W3000072935 @default.
• W3215745906 cites W3000396321 @default.
• W3215745906 cites W3030404886 @default.
• W3215745906 cites W3116148367 @default.
• W3215745906 cites W4211077900 @default.
• W3215745906 doi "https://doi.org/10.1159/000520163" @default.
• W3215745906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34852349" @default.
• W3215745906 hasPublicationYear "2021" @default.
• W3215745906 type Work @default.
• W3215745906 sameAs 3215745906 @default.
• W3215745906 citedByCount "2" @default.
• W3215745906 countsByYear W32157459062022 @default.
• W3215745906 countsByYear W32157459062023 @default.
• W3215745906 crossrefType "journal-article" @default.
• W3215745906 hasAuthorship W3215745906A5002731519 @default.
• W3215745906 hasAuthorship W3215745906A5017523407 @default.
• W3215745906 hasConcept C126322002 @default.
• W3215745906 hasConcept C203014093 @default.
• W3215745906 hasConcept C2776252253 @default.
• W3215745906 hasConcept C2776260265 @default.
• W3215745906 hasConcept C2776914184 @default.
• W3215745906 hasConcept C2777011040 @default.
• W3215745906 hasConcept C2780564577 @default.
• W3215745906 hasConcept C30036603 @default.
• W3215745906 hasConcept C71924100 @default.
• W3215745906 hasConcept C90924648 @default.
• W3215745906 hasConceptScore W3215745906C126322002 @default.
• W3215745906 hasConceptScore W3215745906C203014093 @default.
• W3215745906 hasConceptScore W3215745906C2776252253 @default.
• W3215745906 hasConceptScore W3215745906C2776260265 @default.
• W3215745906 hasConceptScore W3215745906C2776914184 @default.
• W3215745906 hasConceptScore W3215745906C2777011040 @default.
• W3215745906 hasConceptScore W3215745906C2780564577 @default.
• W3215745906 hasConceptScore W3215745906C30036603 @default.
• W3215745906 hasConceptScore W3215745906C71924100 @default.
• W3215745906 hasConceptScore W3215745906C90924648 @default.
• W3215745906 hasIssue "4" @default.
• W3215745906 hasLocation W32157459061 @default.
• W3215745906 hasLocation W32157459062 @default.
• W3215745906 hasOpenAccess W3215745906 @default.
• W3215745906 hasPrimaryLocation W32157459061 @default.
• W3215745906 hasRelatedWork W2042893181 @default.
• W3215745906 hasRelatedWork W2909041485 @default.
• W3215745906 hasRelatedWork W3035020242 @default.
• W3215745906 hasRelatedWork W3128860132 @default.
• W3215745906 hasRelatedWork W3162751674 @default.
• W3215745906 hasRelatedWork W3176363967 @default.
• W3215745906 hasRelatedWork W3185027159 @default.
• W3215745906 hasRelatedWork W3215745906 @default.
• W3215745906 hasRelatedWork W4293216379 @default.
• W3215745906 hasRelatedWork W4366975255 @default.
• W3215745906 hasVolume "238" @default.
• W3215745906 isParatext "false" @default.
• W3215745906 isRetracted "false" @default.
• W3215745906 magId "3215745906" @default.
• W3215745906 workType "article" @default.