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- W3215767807 abstract "DNA capture with high fidelity is an essential part of nanopore translocation. We report several important aspects of the capture process and subsequent translocation of a model DNA polymer through a solid-state nanopore in presence of an extended electric field using the Brownian dynamics simulation that enables us to record statistics of the conformations at every stage of the translocation process. By releasing the equilibrated DNAs from different equipotentials, we observe that the capture time distribution depends on the initial starting point and follows a Poisson process. The field gradient elongates the DNA on its way towards the nanopore and favors a successful translocation even after multiple failed threading attempts. Even in the limit of an extremely narrow pore, a fully flexible chain has a finite probability of hairpin-loop capture while this probability decreases for a stiffer chain and promotes single file translocation. Our studies for the first time identify and differentiate characteristic distributions of the mean first passage time due to single file translocation from those due to translocation of different types of folds and provide direct evidences of the interpretation of the experimentally observed folds [M. Gershow et al., Nat. Nanotech. 2, 775 (2007) & M. Mihovilovic et al. Phys. Rev. Letts. 110, 028102 (2013)] in solitary nanopores." @default.
- W3215767807 created "2021-12-06" @default.
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- W3215767807 date "2021-11-22" @default.
- W3215767807 modified "2023-09-27" @default.
- W3215767807 title "Polymer capture, folds, and translocation in a solitary nanopore" @default.
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