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• W3215788478 abstract "Although considered to be exact copies of each other, sister chromatids can segregate nonrandomly in some cases. For example, sister chromatids of the X and Y chromosomes segregate nonrandomly during asymmetric division of male germline stem cells (GSCs) in Drosophila melanogaster. Here, we demonstrate that the ribosomal DNA (rDNA) loci, which are located on the X and Y chromosomes, and an rDNA binding protein Indra are required for nonrandom sister chromatid segregation (NRSS). We provide the evidence that NRSS, following unequal sister chromatid exchange, is a mechanism by which GSCs recover rDNA copy number, counteracting the spontaneous copy number loss that occurs during aging. Our study reveals an unexpected role for NRSS in maintaining germline immortality through maintenance of a vulnerable genomic element, rDNA." @default.
• W3215788478 created "2021-12-06" @default.
• W3215788478 creator A5006167254 @default.
• W3215788478 creator A5030005228 @default.
• W3215788478 date "2022-07-29" @default.
• W3215788478 modified "2023-09-27" @default.
• W3215788478 title "Nonrandom sister chromatid segregation mediates rDNA copy number maintenance in <i>Drosophila</i>" @default.
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• W3215788478 doi "https://doi.org/10.1126/sciadv.abo4443" @default.
• W3215788478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35895823" @default.
• W3215788478 hasPublicationYear "2022" @default.
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