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• W3215794336 abstract "DNA phosphorothioation (PT) is widely distributed in the human gut microbiome. In this work, PT-diet effect on nematodes was studied with PT-bioengineering bacteria. We found that the ROS level decreased by about 20-50% and the age-related lipofuscin accumulation was reduced by 15-25%. Moreover, the PT-feeding worms were more active at all life periods, and more resistant to acute stressors. Intriguingly, their lifespans were prolonged by ~21.7%. Comparative RNA-seq analysis indicated that many gene expressions were dramatically regulated by PT-diet, such as cysteine-rich protein (scl-11/12/13), sulfur-related enzyme (cpr-2), longevity gene (jnk-1) and stress response (sod-3/5, gps-5/6, gst-18/20, hsp-12.8). Both the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis suggested that neuroactivity pathways were upregulated, while phosphoryl transfer and DNA-repair pathways were down-regulated in good-appetite young worms. The findings pave the way for pro-longevity of multicellular organisms by PT-bacterial interference." @default.
• W3215794336 created "2021-12-06" @default.
• W3215794336 creator A5011936038 @default.
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• W3215794336 date "2021-11-25" @default.
• W3215794336 modified "2023-10-16" @default.
• W3215794336 title "Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity" @default.
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• W3215794336 doi "https://doi.org/10.1038/s42003-021-02863-y" @default.
• W3215794336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34824369" @default.
• W3215794336 hasPublicationYear "2021" @default.
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