Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215851504> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3215851504 endingPage "vi7" @default.
- W3215851504 startingPage "vi7" @default.
- W3215851504 abstract "Abstract PURPOSE Multi-omics data integration captures tumor characteristics at multiple scales [i.e., microscopic (genomics and epigenetics), macroscopic (radiomics), clinical manifestation], provides a more comprehensive assessment of patient’s risk, and facilitates personalized therapies. In this work, we investigated the synergistic value of such multiple data sources for risk stratification and prediction of overall survival in IDH-wildtype glioblastoma tumors. METHODS Quantitative conventional and deep radiomics were extracted from pre-operative multi-parametric structural MRI (T1, T1Gd, T2, T2-FLAIR) of 501 patients with newly diagnosed glioblastoma. 389/501 and 112/501 patients formed our discovery and replication cohorts, respectively. Conventional radiomics were extracted from CaPTk, and deep radiomics from a pre-trained VGG-19 model. Multivariate SVM classification was performed on the discovery cohort to stratify patients in high, medium, and low-risk groups, using recursive feature elimination and 5-fold cross-validation. This model was independently tested on the replication cohort, and a radiomic-based survival prediction index (SPIradiomics) was calculated for each patient. Multi-stage integration of omics data, i.e., clinical (age, gender, extent of resection (EOR)), SPIradiomics, epigenetics (MGMT promoter methylation), and genomics (27 clinically relevant gene mutations via next-generation sequencing (NGS)), was performed using multivariate Cox proportional hazards (Cox-PH) model for stratification of the risk in the replication cohort. RESULTS Cox-PH modeling resulted in a concordance index (c-index) of 0.65 (95% CI:0.6–0.7) for clinical data, 0.67 (95% CI:0.62–0.72) for clinical and epigenetics, 0.70 (95% CI:0.65–0.75) for clinical and radiomics, 0.72 (95% CI:0.68–0.77) for clinical, epigenetics, and radiomics, and 0.75 (95% CI:0.71 – 0.78) for the multi-omics combination of all data; highlighting the added value of each layer of information in prediction of the patient’s risk. CONCLUSION Our results reinforce the synergistic value of integrated diagnostic methods for improving risk assessment of patients with glioblastoma that may pave the path towards a more personalized treatment planning." @default.
- W3215851504 created "2021-12-06" @default.
- W3215851504 creator A5000168473 @default.
- W3215851504 creator A5006742893 @default.
- W3215851504 creator A5010767759 @default.
- W3215851504 creator A5012743558 @default.
- W3215851504 creator A5023567141 @default.
- W3215851504 creator A5025363370 @default.
- W3215851504 creator A5034999945 @default.
- W3215851504 creator A5037606068 @default.
- W3215851504 creator A5037974362 @default.
- W3215851504 creator A5043497448 @default.
- W3215851504 creator A5052402717 @default.
- W3215851504 creator A5064222905 @default.
- W3215851504 creator A5071513506 @default.
- W3215851504 creator A5074569410 @default.
- W3215851504 creator A5079162823 @default.
- W3215851504 creator A5082801249 @default.
- W3215851504 creator A5083616879 @default.
- W3215851504 creator A5090417017 @default.
- W3215851504 date "2021-11-02" @default.
- W3215851504 modified "2023-10-16" @default.
- W3215851504 title "EPCO-25. MULTI-OMICS DISEASE STRATIFICATION IN PATIENTS WITH IDH-WILDTYPE GLIOBLASTOMA: SYNERGISTIC VALUE OF CLINICAL MEASURES, CONVENTIONAL AND DEEP RADIOMICS, AND GENOMICS FOR PREDICTION OF OVERALL SURVIVAL" @default.
- W3215851504 doi "https://doi.org/10.1093/neuonc/noab196.024" @default.
- W3215851504 hasPublicationYear "2021" @default.
- W3215851504 type Work @default.
- W3215851504 sameAs 3215851504 @default.
- W3215851504 citedByCount "1" @default.
- W3215851504 countsByYear W32158515042022 @default.
- W3215851504 crossrefType "journal-article" @default.
- W3215851504 hasAuthorship W3215851504A5000168473 @default.
- W3215851504 hasAuthorship W3215851504A5006742893 @default.
- W3215851504 hasAuthorship W3215851504A5010767759 @default.
- W3215851504 hasAuthorship W3215851504A5012743558 @default.
- W3215851504 hasAuthorship W3215851504A5023567141 @default.
- W3215851504 hasAuthorship W3215851504A5025363370 @default.
- W3215851504 hasAuthorship W3215851504A5034999945 @default.
- W3215851504 hasAuthorship W3215851504A5037606068 @default.
- W3215851504 hasAuthorship W3215851504A5037974362 @default.
- W3215851504 hasAuthorship W3215851504A5043497448 @default.
- W3215851504 hasAuthorship W3215851504A5052402717 @default.
- W3215851504 hasAuthorship W3215851504A5064222905 @default.
- W3215851504 hasAuthorship W3215851504A5071513506 @default.
- W3215851504 hasAuthorship W3215851504A5074569410 @default.
- W3215851504 hasAuthorship W3215851504A5079162823 @default.
- W3215851504 hasAuthorship W3215851504A5082801249 @default.
- W3215851504 hasAuthorship W3215851504A5083616879 @default.
- W3215851504 hasAuthorship W3215851504A5090417017 @default.
- W3215851504 hasBestOaLocation W32158515041 @default.
- W3215851504 hasConcept C126322002 @default.
- W3215851504 hasConcept C143998085 @default.
- W3215851504 hasConcept C160798450 @default.
- W3215851504 hasConcept C50382708 @default.
- W3215851504 hasConcept C60644358 @default.
- W3215851504 hasConcept C70721500 @default.
- W3215851504 hasConcept C71924100 @default.
- W3215851504 hasConcept C72563966 @default.
- W3215851504 hasConcept C86803240 @default.
- W3215851504 hasConceptScore W3215851504C126322002 @default.
- W3215851504 hasConceptScore W3215851504C143998085 @default.
- W3215851504 hasConceptScore W3215851504C160798450 @default.
- W3215851504 hasConceptScore W3215851504C50382708 @default.
- W3215851504 hasConceptScore W3215851504C60644358 @default.
- W3215851504 hasConceptScore W3215851504C70721500 @default.
- W3215851504 hasConceptScore W3215851504C71924100 @default.
- W3215851504 hasConceptScore W3215851504C72563966 @default.
- W3215851504 hasConceptScore W3215851504C86803240 @default.
- W3215851504 hasIssue "Supplement_6" @default.
- W3215851504 hasLocation W32158515041 @default.
- W3215851504 hasOpenAccess W3215851504 @default.
- W3215851504 hasPrimaryLocation W32158515041 @default.
- W3215851504 hasRelatedWork W1411054225 @default.
- W3215851504 hasRelatedWork W2596040508 @default.
- W3215851504 hasRelatedWork W2975501952 @default.
- W3215851504 hasRelatedWork W3104817578 @default.
- W3215851504 hasRelatedWork W3144899533 @default.
- W3215851504 hasRelatedWork W4304808194 @default.
- W3215851504 hasRelatedWork W4309244132 @default.
- W3215851504 hasRelatedWork W4311192294 @default.
- W3215851504 hasRelatedWork W4321445604 @default.
- W3215851504 hasRelatedWork W4366351644 @default.
- W3215851504 hasVolume "23" @default.
- W3215851504 isParatext "false" @default.
- W3215851504 isRetracted "false" @default.
- W3215851504 magId "3215851504" @default.
- W3215851504 workType "article" @default.