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- W3215853430 abstract "<b>Background:</b> Management of ACO is clinically challenging due to insufficient evidence on pathological changes in these patients. <b>Aim:</b> To evaluate large airway remodelling changes in patients with ACO compared to asthma, COPD ex-smokers (ES) and current smokers (CS), non-smoking normal controls (NC), and normal lung function smokers (NLFS). <b>Methods:</b> Endobronchial biopsy tissue from 12 ACO, 14 asthmatics, 12 COPD‑ES, 11 CS, 28 NC, and 13 NLFS were stained with Masson’s trichrome. Epithelial and goblet cells/mm reticular basement membrane (RBM); total lamina propria (LP) cells/mm2 up to 120 µm deep were enumerated for the area surveyed; RBM, epithelial, and smooth muscle (SM) thickness were analysed using imaging software ImageProPlus V7.0. <b>Results:</b> Compared to asthma and COPD, ACO showed differential remodelling pattern. The RBM was significantly thicker in ACO than asthmatics (p <0.04), NC (p <0.0001), NLFS (p <0.03), but not COPD ES (p 0.2316)/CS (p 0.2599). Goblet cells were significantly higher in ACO than COPD-ES (p <0.006) and CS (p <0.04). Further in ACO, RBM cells were higher than the NC (p <0.004), NLFS (p <0.0001), COPD-ES (p <0.0007), and CS (p <0.003), however, did not differ from asthmatics (p 0.4252). LP cells in ACO were significantly higher than COPD-CS (p <0.04); lower than the asthmatics (p <0.02). Finally, SM thickness was significantly lower in ACO than asthmatics (p <0.02), CS (p <0.05), and NLFS (p <0.02). No epithelial changes were seen in ACO as compared to other groups. <b>Conclusions:</b> Our findings suggest that ACO patients had severe tissue remodelling changes than asthmatics and COPD patients." @default.
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- W3215853430 date "2021-09-05" @default.
- W3215853430 modified "2023-10-16" @default.
- W3215853430 title "Airway remodelling augmented in patients with asthma COPD overlap (ACO) compared to asthma and COPD" @default.
- W3215853430 doi "https://doi.org/10.1183/13993003.congress-2021.pa665" @default.
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