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- W3215911517 abstract "<b>Background:</b> In hospitalized COPD-patients, initial therapy will target breathing symptoms, and include oxygen administration and often include morphine and/or benzodiazepines. This will, according to current literature, increase the risk of adverse events. Only few studies have examined the risk of adverse events in hospital settings systematically, and none are based on consecutive data from the initial hours of admission. <b>Aims and Objectives:</b> To investigate if there is an association between oxygen therapy, SpO<sub>2,</sub> morphine, benzodiazepines and adverse events. <b>Methods:</b> An observational study on consecutive patients (n=300) admitted with COPD exacerbation and receiving oxygen in four hospitals in the capital region of Denmark. Data on oxygen and SpO2 were obtained at arrival and by intervals of 8 hours until 24 hours. Administration of morphine and benzodiazepines were obtained from the first three nurse-shifts. Adverse events were defined as mechanical ventilation (MV) during admission or death within 14 days from admission. <b>Results:</b> A multivariate analysis adjusted for age, gender, respiration frequency and comorbidities; we found no significant associations between oxygen flow, SpO2, benzodiazepines and adverse events. There was, however, a significant association between long-term oxygen therapy and the risk of MV (p=0.016), but no significant association to death. Use of morphine was significantly associated with both MV (p=0.029) and death (p=0.043). <b>Conclusion:</b> SpO2 and oxygen flow were not associated with adverse outcomes, which was surprising considering previous studies, but opioid drugs were strongly associated with a poor prognosis." @default.
- W3215911517 created "2021-12-06" @default.
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- W3215911517 date "2021-09-05" @default.
- W3215911517 modified "2023-09-27" @default.
- W3215911517 title "Oxygen therapy within first 24 hours of admission in patients with COPD and risk of adverse events - an observational study" @default.
- W3215911517 doi "https://doi.org/10.1183/13993003.congress-2021.pa3839" @default.
- W3215911517 hasPublicationYear "2021" @default.
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